Mass spectral studies of snake venoms and some of their toxins

Kemmons A. Tubbs, Randall W. Nelson, Jennifer R. Krone, Allan L. Bleber

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The profound effect of Biological Mass Spectrometry (MS) on protein analysis has been amplified by recent developments in analytically based matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF MS). This review provides a brief synapses of snake toxin based research allocating mass spectrometric immunoassay (MSIA) and bioreactive probe tips technologies. Contingent upon advances in Biological MS has been the movement of mass spectrometric applications into array based technology. Biomolecular interaction analysis interfaced with mass spectrometry (BIA/MS) exemplifies the diverse potential of chip based techniques, combining the powerful front-end analysis of biological interaction events with the dynamic precision of MALDI-MS mass specific assignment, to demonstrate 'lab on a chip' technology. Analysis of other snake venoms and related toxins by electrospray ionization and tandem mass spectrometry as well as capillary electrophoresis combined with MALDI-MS are included.

Original languageEnglish (US)
Pages (from-to)1-22
Number of pages22
JournalJournal of Toxicology - Toxin Reviews
Volume19
Issue number1
DOIs
StatePublished - 2000

Fingerprint

Snake Venoms
Mass spectrometry
Mass Spectrometry
Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry
Technology
Electrospray Ionization Mass Spectrometry
Snakes
Capillary Electrophoresis
Capillary electrophoresis
Lab-on-a-chip
Electrospray ionization
Tandem Mass Spectrometry
Immunoassay
Synapses
Lasers
Ionization
Desorption
Research
Proteins

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Toxicology

Cite this

Mass spectral studies of snake venoms and some of their toxins. / Tubbs, Kemmons A.; Nelson, Randall W.; Krone, Jennifer R.; Bleber, Allan L.

In: Journal of Toxicology - Toxin Reviews, Vol. 19, No. 1, 2000, p. 1-22.

Research output: Contribution to journalArticle

Tubbs, Kemmons A. ; Nelson, Randall W. ; Krone, Jennifer R. ; Bleber, Allan L. / Mass spectral studies of snake venoms and some of their toxins. In: Journal of Toxicology - Toxin Reviews. 2000 ; Vol. 19, No. 1. pp. 1-22.
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