Mass spectra of nucleoside components of tRNA

Sidney M. Hecht, Amrit S. Gupta, Nelson J. Leonard

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

Low resolution mass spectra have been recorded at 20 eV and 70 eV under comparable conditions for a series of nucleosides which are components, or possible components, of tRNA: pseudouridine, 5,6-dihydrouridine, 5-methylcytidine, ribothymidine, 3-methyluridine, inosine, 1-methyladenosine, N6-methyladenosine, 1-methylinosine, guanosine, N4-acetylcytidine, N6, N6-dimethyladenosine, N2-methylguanosine, 1-methylguanosine, 7-methylguanosine, and 2-methoxyadenosine. These spectra can be used for the identification of presently known nucleosides and for the identification of newly isolated ribosides by consideration of their fragmentation patterns relative to those of the known compounds.

Original languageEnglish (US)
Pages (from-to)249-270
Number of pages22
JournalAnalytical Biochemistry
Volume30
Issue number2
DOIs
StatePublished - Aug 1969
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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