Management of osteoporosis, fat-soluble vitamin deficiencies, and hyperlipidemia in primary biliary cirrhosis

Cynthia Levy, Keith D. Lindor

Research output: Contribution to journalReview article

32 Scopus citations


Osteoporosis is several times more common in patients with PBC compared with the general population. Maintaining adequate intake of calcium and vitamin D is important for prevention of bone loss. The use of bisphosphonates or vitamin K to improve bone mineral density in osteopenic patients seems promising and needs to be further evaluated. Patients with PBC may develop fat-soluble vitamin deficiencies, especially vitamins A and D; serum levels should be investigated in patients considered at risk with the aim of recommending appropriate replacement therapy. Finally, hyperlipidemia in PBC does not seem to be associated with an increased risk of atherogenesis. New therapies in this patient population are currently under investigation.

Original languageEnglish (US)
Pages (from-to)901-910
Number of pages10
JournalClinics in liver disease
Issue number4
StatePublished - Nov 2003
Externally publishedYes


ASJC Scopus subject areas

  • Hepatology

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