Localized cell lysis by self focused acoustic transducers

J. Zhu, X. Qiu, J. Oiler, C. Yu, Z. Wang, C. Lee, T. K. Hsiai, E. S. Kim, H. Yu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Scopus citations

Abstract

This paper presents localized cell lysis using a Self Focused Acoustic Transducer (SFAT). The 18 MHz acoustic waves generated by the SFAT focus at a spot of around 100 μm in diameter with a peak intensity of 25 W/cm 2, which is strong enough to produce acoustic cavitation at such high frequency. With the great pressure and temperature produced by the cavitation, cells are broken and detached in a tiny area from the substrate while leaving other ones intact. That is ideal for localized cell lysis and killing tumors. Moreover, the gene analysis is conducted to confirm that the lysis effect is due to the high intensity of focused acoustic waves.

Original languageEnglish (US)
Title of host publicationTRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems
Pages608-611
Number of pages4
DOIs
StatePublished - 2009
EventTRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems - Denver, CO, United States
Duration: Jun 21 2009Jun 25 2009

Publication series

NameTRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems

Other

OtherTRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems
CountryUnited States
CityDenver, CO
Period6/21/096/25/09

Keywords

  • Acoustic cavitation
  • Cell lysis
  • SFAT

ASJC Scopus subject areas

  • Hardware and Architecture
  • Electrical and Electronic Engineering

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