Leveraging the dynamic blood–brain barrier for central nervous system nanoparticle-based drug delivery applications

Connor Copeland, Sarah E. Stabenfeldt

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Neurological diseases and injuries have profound impact on a patient's lifespan and functional capabilities, but often lack effective intervention strategies to address the underlying neuropathology. The blood–brain barrier is a major hurdle in the effective delivery of therapeutics to the brain. Recent discoveries in blood–brain barrier maintenance reveal a dynamic system where time of day, disease progression, and even biological variables all strongly influence its permeability and flux of molecules. Nanoparticles can be used to improve the efficacy of therapeutics by increasing circulation time, bioavailability, selectivity, and controlling the rate of payload release. Considering these recent findings, the next generation of pharmacological paradigms are evolving to leverage nanotechnology to turn therapeutic intervention to meet the needs of a specific patient (i.e. personalized medicine).

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalCurrent Opinion in Biomedical Engineering
Volume14
DOIs
StatePublished - Jun 2020

Keywords

  • Blood–brain barrier
  • Circadian rhythm
  • Drug delivery
  • Nanoparticle
  • Traumatic brain injury

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Bioengineering
  • Medicine (miscellaneous)

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