Abstract
Investigation of Pseudomonas syringae pv. coronafaciens cancer cell growth inhibitory constituents led to the isolation of 2-isobutyl-5-(3-indolyl)oxazole (1) and 2-n-pentyl-5-(3-indolyl)oxazole (2f), designated labradorins 1 (1) and 2 (2f), related to pimprinine (2a). The structures were deduced by spectroscopic techniques and X-ray crystal structure determinations. Labradorin 1 (1) afforded GI50 μg/mL values of 9.8 and 6.2 against the human cancer cell lines NCI-H 460 (lung-NSC) and BXPC-3 (pancreas-a).
Original language | English (US) |
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Pages (from-to) | 1793-1797 |
Number of pages | 5 |
Journal | Journal of Natural Products |
Volume | 65 |
Issue number | 12 |
DOIs | |
State | Published - Dec 1 2002 |
ASJC Scopus subject areas
- Analytical Chemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry
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CCDC 211569: Experimental Crystal Structure Determination
Pettit, G. R. (Creator), Knight, J. C. (Creator), Herald, D. L. (Creator), Davenport, R. (Creator), Pettit, R. K. (Creator), Tucker, B. E. (Creator), Schmidt, J. M. (Creator) & Pettit, G. R. (Creator), The Cambridge Structural Database, 2003
DOI: 10.5517/cc734t8, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cc734t8&sid=DataCite
Dataset
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CCDC 211568: Experimental Crystal Structure Determination
Pettit, G. R. (Creator), Knight, J. C. (Creator), Herald, D. L. (Creator), Davenport, R. (Creator), Pettit, R. K. (Creator), Tucker, B. E. (Creator), Schmidt, J. M. (Creator) & Pettit, G. R. (Creator), The Cambridge Structural Database, 2003
DOI: 10.5517/cc734s7, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cc734s7&sid=DataCite
Dataset
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CCDC 211570: Experimental Crystal Structure Determination
Pettit, G. R. (Creator), Knight, J. C. (Creator), Herald, D. L. (Creator), Davenport, R. (Creator), Pettit, R. K. (Creator), Tucker, B. E. (Creator), Schmidt, J. M. (Creator) & Pettit, G. R. (Creator), The Cambridge Structural Database, 2003
DOI: 10.5517/cc734v9, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cc734v9&sid=DataCite
Dataset