Isolation of labradorins 1 and 2 from Pseudomonas syringae pv. coronafaciens

George Pettit; John C. Knight; Delbert L. Herald; Richard Davenport; Robin Pettit; Bruce E. Tucker; Jean M. Schmidt

doi:10.1021/np020173x

Isolation of labradorins 1 and 2 from Pseudomonas syringae pv. coronafaciens

George Pettit, John C. Knight, Delbert L. Herald, Richard Davenport, Robin Pettit, Bruce E. Tucker, Jean M. Schmidt

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Abstract

Investigation of Pseudomonas syringae pv. coronafaciens cancer cell growth inhibitory constituents led to the isolation of 2-isobutyl-5-(3-indolyl)oxazole (1) and 2-n-pentyl-5-(3-indolyl)oxazole (2f), designated labradorins 1 (1) and 2 (2f), related to pimprinine (2a). The structures were deduced by spectroscopic techniques and X-ray crystal structure determinations. Labradorin 1 (1) afforded GI₅₀ μg/mL values of 9.8 and 6.2 against the human cancer cell lines NCI-H 460 (lung-NSC) and BXPC-3 (pancreas-a).

Original language	English (US)
Pages (from-to)	1793-1797
Number of pages	5
Journal	Journal of Natural Products
Volume	65
Issue number	12
DOIs	https://doi.org/10.1021/np020173x
State	Published - Dec 1 2002

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np020173x

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title = "Isolation of labradorins 1 and 2 from Pseudomonas syringae pv. coronafaciens",

abstract = "Investigation of Pseudomonas syringae pv. coronafaciens cancer cell growth inhibitory constituents led to the isolation of 2-isobutyl-5-(3-indolyl)oxazole (1) and 2-n-pentyl-5-(3-indolyl)oxazole (2f), designated labradorins 1 (1) and 2 (2f), related to pimprinine (2a). The structures were deduced by spectroscopic techniques and X-ray crystal structure determinations. Labradorin 1 (1) afforded GI50 μg/mL values of 9.8 and 6.2 against the human cancer cell lines NCI-H 460 (lung-NSC) and BXPC-3 (pancreas-a).",

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T1 - Isolation of labradorins 1 and 2 from Pseudomonas syringae pv. coronafaciens

AU - Pettit, George

AU - Knight, John C.

AU - Herald, Delbert L.

AU - Davenport, Richard

AU - Pettit, Robin

AU - Tucker, Bruce E.

AU - Schmidt, Jean M.

PY - 2002/12/1

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AB - Investigation of Pseudomonas syringae pv. coronafaciens cancer cell growth inhibitory constituents led to the isolation of 2-isobutyl-5-(3-indolyl)oxazole (1) and 2-n-pentyl-5-(3-indolyl)oxazole (2f), designated labradorins 1 (1) and 2 (2f), related to pimprinine (2a). The structures were deduced by spectroscopic techniques and X-ray crystal structure determinations. Labradorin 1 (1) afforded GI50 μg/mL values of 9.8 and 6.2 against the human cancer cell lines NCI-H 460 (lung-NSC) and BXPC-3 (pancreas-a).

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