Abstract
Investigation of Pseudomonas syringae pv. coronafaciens cancer cell growth inhibitory constituents led to the isolation of 2-isobutyl-5-(3-indolyl)oxazole (1) and 2-n-pentyl-5-(3-indolyl)oxazole (2f), designated labradorins 1 (1) and 2 (2f), related to pimprinine (2a). The structures were deduced by spectroscopic techniques and X-ray crystal structure determinations. Labradorin 1 (1) afforded GI50 μg/mL values of 9.8 and 6.2 against the human cancer cell lines NCI-H 460 (lung-NSC) and BXPC-3 (pancreas-a).
Original language | English (US) |
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Pages (from-to) | 1793-1797 |
Number of pages | 5 |
Journal | Journal of Natural Products |
Volume | 65 |
Issue number | 12 |
DOIs | |
State | Published - Dec 1 2002 |
ASJC Scopus subject areas
- Analytical Chemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry
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CCDC 211569: Experimental Crystal Structure Determination
Pettit, G. R. (Creator), Knight, J. C. (Creator), Herald, D. L. (Creator), Davenport, R. (Creator), Pettit, R. K. (Creator), Tucker, B. E. (Creator) & Schmidt, J. M. (Creator), The Cambridge Structural Database, 2003
DOI: 10.5517/cc734t8, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cc734t8&sid=DataCite
Dataset
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CCDC 211570: Experimental Crystal Structure Determination
Pettit, G. R. (Creator), Knight, J. C. (Creator), Herald, D. L. (Creator), Davenport, R. (Creator), Pettit, R. K. (Creator), Tucker, B. E. (Creator) & Schmidt, J. M. (Creator), The Cambridge Structural Database, 2003
DOI: 10.5517/cc734v9, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cc734v9&sid=DataCite
Dataset
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CCDC 211568: Experimental Crystal Structure Determination
Pettit, G. R. (Creator), Knight, J. C. (Creator), Herald, D. L. (Creator), Davenport, R. (Creator), Pettit, R. K. (Creator), Tucker, B. E. (Creator) & Schmidt, J. M. (Creator), The Cambridge Structural Database, 2003
DOI: 10.5517/cc734s7, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cc734s7&sid=DataCite
Dataset