Isolation of labradorins 1 and 2 from Pseudomonas syringae pv. coronafaciens

George Pettit; John C. Knight; Delbert L. Herald; Richard Davenport; Robin Pettit; Bruce E. Tucker; Jean M. Schmidt

doi:10.1021/np020173x

Isolation of labradorins 1 and 2 from Pseudomonas syringae pv. coronafaciens

George Pettit, John C. Knight, Delbert L. Herald, Richard Davenport, Robin Pettit, Bruce E. Tucker, Jean M. Schmidt

Research output: Contribution to journal › Article › peer-review

66 Scopus citations

Abstract

Investigation of Pseudomonas syringae pv. coronafaciens cancer cell growth inhibitory constituents led to the isolation of 2-isobutyl-5-(3-indolyl)oxazole (1) and 2-n-pentyl-5-(3-indolyl)oxazole (2f), designated labradorins 1 (1) and 2 (2f), related to pimprinine (2a). The structures were deduced by spectroscopic techniques and X-ray crystal structure determinations. Labradorin 1 (1) afforded GI₅₀ μg/mL values of 9.8 and 6.2 against the human cancer cell lines NCI-H 460 (lung-NSC) and BXPC-3 (pancreas-a).

Original language	English (US)
Pages (from-to)	1793-1797
Number of pages	5
Journal	Journal of Natural Products
Volume	65
Issue number	12
DOIs	https://doi.org/10.1021/np020173x
State	Published - Dec 1 2002

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

Access to Document

10.1021/np020173x

Cite this

@article{5e4d91e2c93d4dd4a584fcf5925223dc,

title = "Isolation of labradorins 1 and 2 from Pseudomonas syringae pv. coronafaciens",

abstract = "Investigation of Pseudomonas syringae pv. coronafaciens cancer cell growth inhibitory constituents led to the isolation of 2-isobutyl-5-(3-indolyl)oxazole (1) and 2-n-pentyl-5-(3-indolyl)oxazole (2f), designated labradorins 1 (1) and 2 (2f), related to pimprinine (2a). The structures were deduced by spectroscopic techniques and X-ray crystal structure determinations. Labradorin 1 (1) afforded GI50 μg/mL values of 9.8 and 6.2 against the human cancer cell lines NCI-H 460 (lung-NSC) and BXPC-3 (pancreas-a).",

author = "George Pettit and Knight, {John C.} and Herald, {Delbert L.} and Richard Davenport and Robin Pettit and Tucker, {Bruce E.} and Schmidt, {Jean M.}",

year = "2002",

month = dec,

day = "1",

doi = "10.1021/np020173x",

language = "English (US)",

volume = "65",

pages = "1793--1797",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

number = "12",

}

TY - JOUR

T1 - Isolation of labradorins 1 and 2 from Pseudomonas syringae pv. coronafaciens

AU - Pettit, George

AU - Knight, John C.

AU - Herald, Delbert L.

AU - Davenport, Richard

AU - Pettit, Robin

AU - Tucker, Bruce E.

AU - Schmidt, Jean M.

PY - 2002/12/1

Y1 - 2002/12/1

N2 - Investigation of Pseudomonas syringae pv. coronafaciens cancer cell growth inhibitory constituents led to the isolation of 2-isobutyl-5-(3-indolyl)oxazole (1) and 2-n-pentyl-5-(3-indolyl)oxazole (2f), designated labradorins 1 (1) and 2 (2f), related to pimprinine (2a). The structures were deduced by spectroscopic techniques and X-ray crystal structure determinations. Labradorin 1 (1) afforded GI50 μg/mL values of 9.8 and 6.2 against the human cancer cell lines NCI-H 460 (lung-NSC) and BXPC-3 (pancreas-a).

AB - Investigation of Pseudomonas syringae pv. coronafaciens cancer cell growth inhibitory constituents led to the isolation of 2-isobutyl-5-(3-indolyl)oxazole (1) and 2-n-pentyl-5-(3-indolyl)oxazole (2f), designated labradorins 1 (1) and 2 (2f), related to pimprinine (2a). The structures were deduced by spectroscopic techniques and X-ray crystal structure determinations. Labradorin 1 (1) afforded GI50 μg/mL values of 9.8 and 6.2 against the human cancer cell lines NCI-H 460 (lung-NSC) and BXPC-3 (pancreas-a).

UR - http://www.scopus.com/inward/record.url?scp=0036928561&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036928561&partnerID=8YFLogxK

U2 - 10.1021/np020173x

DO - 10.1021/np020173x

M3 - Article

C2 - 12502316

AN - SCOPUS:0036928561

SN - 0163-3864

VL - 65

SP - 1793

EP - 1797

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 12

ER -

Isolation of labradorins 1 and 2 from Pseudomonas syringae pv. coronafaciens

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

CCDC 211569: Experimental Crystal Structure Determination

CCDC 211570: Experimental Crystal Structure Determination

CCDC 211568: Experimental Crystal Structure Determination

Cite this

Isolation of labradorins 1 and 2 from Pseudomonas syringae pv. coronafaciens

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Datasets

CCDC 211569: Experimental Crystal Structure Determination

CCDC 211570: Experimental Crystal Structure Determination

CCDC 211568: Experimental Crystal Structure Determination

Cite this