Isolation of labradorins 1 and 2 from Pseudomonas syringae pv. coronafaciens

George Pettit, John C. Knight, Delbert L. Herald, Richard Davenport, Robin Pettit, Bruce E. Tucker, Jean M. Schmidt

Research output: Contribution to journalArticle

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Abstract

Investigation of Pseudomonas syringae pv. coronafaciens cancer cell growth inhibitory constituents led to the isolation of 2-isobutyl-5-(3-indolyl)oxazole (1) and 2-n-pentyl-5-(3-indolyl)oxazole (2f), designated labradorins 1 (1) and 2 (2f), related to pimprinine (2a). The structures were deduced by spectroscopic techniques and X-ray crystal structure determinations. Labradorin 1 (1) afforded GI50 μg/mL values of 9.8 and 6.2 against the human cancer cell lines NCI-H 460 (lung-NSC) and BXPC-3 (pancreas-a).

Original languageEnglish (US)
Pages (from-to)1793-1797
Number of pages5
JournalJournal of Natural Products
Volume65
Issue number12
DOIs
StatePublished - Dec 1 2002

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ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Cite this

Pettit, G., Knight, J. C., Herald, D. L., Davenport, R., Pettit, R., Tucker, B. E., & Schmidt, J. M. (2002). Isolation of labradorins 1 and 2 from Pseudomonas syringae pv. coronafaciens. Journal of Natural Products, 65(12), 1793-1797. https://doi.org/10.1021/np020173x