Isolation of labradorins 1 and 2 from Pseudomonas syringae pv. coronafaciens

George Pettit; John C. Knight; Delbert L. Herald; Richard Davenport; Robin Pettit; Bruce E. Tucker; Jean M. Schmidt

doi:10.1021/np020173x

Isolation of labradorins 1 and 2 from Pseudomonas syringae pv. coronafaciens

George Pettit, John C. Knight, Delbert L. Herald, Richard Davenport, Robin Pettit, Bruce E. Tucker, Jean M. Schmidt

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54 Scopus citations

Abstract

Investigation of Pseudomonas syringae pv. coronafaciens cancer cell growth inhibitory constituents led to the isolation of 2-isobutyl-5-(3-indolyl)oxazole (1) and 2-n-pentyl-5-(3-indolyl)oxazole (2f), designated labradorins 1 (1) and 2 (2f), related to pimprinine (2a). The structures were deduced by spectroscopic techniques and X-ray crystal structure determinations. Labradorin 1 (1) afforded GI₅₀ μg/mL values of 9.8 and 6.2 against the human cancer cell lines NCI-H 460 (lung-NSC) and BXPC-3 (pancreas-a).

Original language	English (US)
Pages (from-to)	1793-1797
Number of pages	5
Journal	Journal of Natural Products
Volume	65
Issue number	12
DOIs	https://doi.org/10.1021/np020173x
State	Published - Dec 1 2002

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ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

Cite this

Pettit, G., Knight, J. C., Herald, D. L., Davenport, R., Pettit, R., Tucker, B. E., & Schmidt, J. M. (2002). Isolation of labradorins 1 and 2 from Pseudomonas syringae pv. coronafaciens. Journal of Natural Products, 65(12), 1793-1797. https://doi.org/10.1021/np020173x

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abstract = "Investigation of Pseudomonas syringae pv. coronafaciens cancer cell growth inhibitory constituents led to the isolation of 2-isobutyl-5-(3-indolyl)oxazole (1) and 2-n-pentyl-5-(3-indolyl)oxazole (2f), designated labradorins 1 (1) and 2 (2f), related to pimprinine (2a). The structures were deduced by spectroscopic techniques and X-ray crystal structure determinations. Labradorin 1 (1) afforded GI50 μg/mL values of 9.8 and 6.2 against the human cancer cell lines NCI-H 460 (lung-NSC) and BXPC-3 (pancreas-a).",

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10.1021/np020173x