Isolation and structure of rolliniastatin 1 from the South American tree Rolliniamucosa

George Pettit, G. M. Cragg, J. Polonsky

Research output: Contribution to journalArticle

72 Scopus citations

Abstract

Rollinin mucosa (Annonaceae), known in primitive medical practices of Indonesia and the West Indies as a treatment for tumors, has been investigated employing the seeds from a South American variety and the murine P388 lymphocytic leukemia (PS) for bioassay. The principal antineoplastic constituent (PS, 28% life extension, at 0.25 mg/kg and ED504.5 × 10-5μg/mL) was found to be a new bis-tetrahydrofuran designated rolliniastatin 1. Structural elucidation of rolliniastatin 1 was accomplished by a combination of high resolution nuclear magnetic resonance (300 MHz), mass spectral, and X-ray crystal structure techniques.

Original languageEnglish (US)
Pages (from-to)1433-1435
Number of pages3
JournalCanadian Journal of Chemistry
Volume65
Issue number6
DOIs
StatePublished - Jun 1 1987

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Organic Chemistry

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