Is selection relevant in the evolutionary emergence of drug resistance?

Troy Day, Silvie Huijben, Andrew F. Read

Research output: Contribution to journalReview article

35 Citations (Scopus)

Abstract

The emergence of drug-resistant pathogens is often considered a canonical case of evolution by natural selection. Here we argue that the strength of selection can be a poor predictor of the rate of resistance emergence. It is possible for a resistant strain to be under negative selection and still emerge in an infection or spread in a population. Measuring the right parameters is a necessary first step toward the development of evidence-based resistance-management strategies. We argue that it is the absolute fitness of the resistant strains that matters most and that a primary determinant of the absolute fitness of a resistant strain is the ecological context in which it finds itself.

Original languageEnglish (US)
Pages (from-to)126-133
Number of pages8
JournalTrends in Microbiology
Volume23
Issue number3
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Fingerprint

Genetic Selection
Drug Resistance
Infection
Pharmaceutical Preparations
Population

Keywords

  • Antibiotics
  • Chemotherapy
  • Evolutionary rescue
  • Mutant selection window

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases
  • Virology

Cite this

Is selection relevant in the evolutionary emergence of drug resistance? / Day, Troy; Huijben, Silvie; Read, Andrew F.

In: Trends in Microbiology, Vol. 23, No. 3, 01.01.2015, p. 126-133.

Research output: Contribution to journalReview article

@article{4e45abba8c384f96b8964905aad8b362,
title = "Is selection relevant in the evolutionary emergence of drug resistance?",
abstract = "The emergence of drug-resistant pathogens is often considered a canonical case of evolution by natural selection. Here we argue that the strength of selection can be a poor predictor of the rate of resistance emergence. It is possible for a resistant strain to be under negative selection and still emerge in an infection or spread in a population. Measuring the right parameters is a necessary first step toward the development of evidence-based resistance-management strategies. We argue that it is the absolute fitness of the resistant strains that matters most and that a primary determinant of the absolute fitness of a resistant strain is the ecological context in which it finds itself.",
keywords = "Antibiotics, Chemotherapy, Evolutionary rescue, Mutant selection window",
author = "Troy Day and Silvie Huijben and Read, {Andrew F.}",
year = "2015",
month = "1",
day = "1",
doi = "10.1016/j.tim.2015.01.005",
language = "English (US)",
volume = "23",
pages = "126--133",
journal = "Trends in Microbiology",
issn = "0966-842X",
publisher = "Elsevier Limited",
number = "3",

}

TY - JOUR

T1 - Is selection relevant in the evolutionary emergence of drug resistance?

AU - Day, Troy

AU - Huijben, Silvie

AU - Read, Andrew F.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - The emergence of drug-resistant pathogens is often considered a canonical case of evolution by natural selection. Here we argue that the strength of selection can be a poor predictor of the rate of resistance emergence. It is possible for a resistant strain to be under negative selection and still emerge in an infection or spread in a population. Measuring the right parameters is a necessary first step toward the development of evidence-based resistance-management strategies. We argue that it is the absolute fitness of the resistant strains that matters most and that a primary determinant of the absolute fitness of a resistant strain is the ecological context in which it finds itself.

AB - The emergence of drug-resistant pathogens is often considered a canonical case of evolution by natural selection. Here we argue that the strength of selection can be a poor predictor of the rate of resistance emergence. It is possible for a resistant strain to be under negative selection and still emerge in an infection or spread in a population. Measuring the right parameters is a necessary first step toward the development of evidence-based resistance-management strategies. We argue that it is the absolute fitness of the resistant strains that matters most and that a primary determinant of the absolute fitness of a resistant strain is the ecological context in which it finds itself.

KW - Antibiotics

KW - Chemotherapy

KW - Evolutionary rescue

KW - Mutant selection window

UR - http://www.scopus.com/inward/record.url?scp=84936986192&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84936986192&partnerID=8YFLogxK

U2 - 10.1016/j.tim.2015.01.005

DO - 10.1016/j.tim.2015.01.005

M3 - Review article

VL - 23

SP - 126

EP - 133

JO - Trends in Microbiology

JF - Trends in Microbiology

SN - 0966-842X

IS - 3

ER -