Interaction of serum antibodies from breast cancer patients with synthetic peptides

S. V. Podlesnykh, E. A. Kolosova, D. N. Shcherbakov, A. A. Shaidurov, D. S. Anisimov, M. A. Ryazanov, Stephen Johnston, Ya N. Shoikhet, V. D. Petrova, A. F. Lazarev, Andrei Chapoval

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

The blood serum of tumor patients contains antibodies recognizing tumor-associated antigens and other molecular products of tumor growth. We studied the interaction of blood antibodies from breast cancer patients with synthetic peptides that were applied on the microchip surface. The serum from healthy volunteers and breast cancer patients was shown to contain antibodies that interact with various peptides. Statistically signifi cant between-group differences were observed in the level of binding with 122 informative peptides (0.01% of the total number of peptides on a microchip). Analysis of antibodies that interact with the peptide panel holds much promise for the diagnostics of breast cancer.

Original languageEnglish (US)
Pages (from-to)816-820
Number of pages5
JournalBulletin of Experimental Biology and Medicine
Volume161
Issue number6
DOIs
StatePublished - Oct 1 2016

Keywords

  • Antibodies
  • Breast cancer
  • Epitopes
  • Mimotopes
  • Peptides microchips

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Podlesnykh, S. V., Kolosova, E. A., Shcherbakov, D. N., Shaidurov, A. A., Anisimov, D. S., Ryazanov, M. A., Johnston, S., Shoikhet, Y. N., Petrova, V. D., Lazarev, A. F., & Chapoval, A. (2016). Interaction of serum antibodies from breast cancer patients with synthetic peptides. Bulletin of Experimental Biology and Medicine, 161(6), 816-820. https://doi.org/10.1007/s10517-016-3519-7