Insulin-like growth factor-I is inversely related to adiposity in overweight Latino children

Claudia M. Toledo-Corral, Christian K. Roberts, Gabriel Shaibi, Christianne J. Lane, Paul B. Higgins, Jaimie N. Davis, Marc J. Weigensberg, Michael I. Goran

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The purpose of this study was to examine interrelationships between IGF-I, IGF binding proteins (IGFBPs) and adiposity in 178 overweight Hispanic adolescents (11.2 ± 1.7 yr; body mass index: 28.2 ± 5.4 kg/m2). Immunoradiometric assays were used to measure IGF-I, IGFBP-1 and IGFBP-3. Total fat and lean tissue mass were measured by DEXA and visceral and subcutaneous adipose tissue by MRI. IGF-I and IGFBP-3 remained inversely correlated with total body fat mass (r = -0.52, p <0.001 and r = -0.25, p <0.01, respectively) after controlling for covariates. IGFBP-1 was inversely correlated to total fat mass (r = -0.55, p <0.001) in simple correlations; however, this relationship was eliminated after controlling for covariates (r = 0.02, p = 0.85). Correlations with visceral and subcutaneous adipose tissue yielded similar results. These results demonstrate that IGF-I, IGFBP-1 and IGFBP-3 are all inversely related to adiposity in Hispanic children.

Original languageEnglish (US)
Pages (from-to)855-864
Number of pages10
JournalJournal of Pediatric Endocrinology and Metabolism
Volume21
Issue number9
DOIs
StatePublished - Sep 2008

Keywords

  • Children
  • IGF
  • IGFBP-1
  • IGFBP-3
  • Obesity
  • Visceral fat

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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