Insulin-like growth factor-I is inversely related to adiposity in overweight Latino children

Claudia M. Toledo-Corral, Christian K. Roberts, Gabriel Shaibi, Christianne J. Lane, Paul B. Higgins, Jaimie N. Davis, Marc J. Weigensberg, Michael I. Goran

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The purpose of this study was to examine interrelationships between IGF-I, IGF binding proteins (IGFBPs) and adiposity in 178 overweight Hispanic adolescents (11.2 ± 1.7 yr; body mass index: 28.2 ± 5.4 kg/m2). Immunoradiometric assays were used to measure IGF-I, IGFBP-1 and IGFBP-3. Total fat and lean tissue mass were measured by DEXA and visceral and subcutaneous adipose tissue by MRI. IGF-I and IGFBP-3 remained inversely correlated with total body fat mass (r = -0.52, p <0.001 and r = -0.25, p <0.01, respectively) after controlling for covariates. IGFBP-1 was inversely correlated to total fat mass (r = -0.55, p <0.001) in simple correlations; however, this relationship was eliminated after controlling for covariates (r = 0.02, p = 0.85). Correlations with visceral and subcutaneous adipose tissue yielded similar results. These results demonstrate that IGF-I, IGFBP-1 and IGFBP-3 are all inversely related to adiposity in Hispanic children.

Original languageEnglish (US)
Pages (from-to)855-864
Number of pages10
JournalJournal of Pediatric Endocrinology and Metabolism
Volume21
Issue number9
StatePublished - Sep 2008

Fingerprint

Adiposity
Insulin-Like Growth Factor I
Insulin-Like Growth Factor Binding Protein 1
Hispanic Americans
Insulin-Like Growth Factor Binding Protein 3
Intra-Abdominal Fat
Subcutaneous Fat
Fats
Immunoradiometric Assay
Insulin-Like Growth Factor Binding Proteins
Adipose Tissue
Body Mass Index

Keywords

  • Children
  • IGF
  • IGFBP-1
  • IGFBP-3
  • Obesity
  • Visceral fat

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Pediatrics, Perinatology, and Child Health

Cite this

Toledo-Corral, C. M., Roberts, C. K., Shaibi, G., Lane, C. J., Higgins, P. B., Davis, J. N., ... Goran, M. I. (2008). Insulin-like growth factor-I is inversely related to adiposity in overweight Latino children. Journal of Pediatric Endocrinology and Metabolism, 21(9), 855-864.

Insulin-like growth factor-I is inversely related to adiposity in overweight Latino children. / Toledo-Corral, Claudia M.; Roberts, Christian K.; Shaibi, Gabriel; Lane, Christianne J.; Higgins, Paul B.; Davis, Jaimie N.; Weigensberg, Marc J.; Goran, Michael I.

In: Journal of Pediatric Endocrinology and Metabolism, Vol. 21, No. 9, 09.2008, p. 855-864.

Research output: Contribution to journalArticle

Toledo-Corral, CM, Roberts, CK, Shaibi, G, Lane, CJ, Higgins, PB, Davis, JN, Weigensberg, MJ & Goran, MI 2008, 'Insulin-like growth factor-I is inversely related to adiposity in overweight Latino children', Journal of Pediatric Endocrinology and Metabolism, vol. 21, no. 9, pp. 855-864.
Toledo-Corral, Claudia M. ; Roberts, Christian K. ; Shaibi, Gabriel ; Lane, Christianne J. ; Higgins, Paul B. ; Davis, Jaimie N. ; Weigensberg, Marc J. ; Goran, Michael I. / Insulin-like growth factor-I is inversely related to adiposity in overweight Latino children. In: Journal of Pediatric Endocrinology and Metabolism. 2008 ; Vol. 21, No. 9. pp. 855-864.
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