TY - JOUR
T1 - Insulin-like growth factor-I is inversely related to adiposity in overweight Latino children
AU - Toledo-Corral, Claudia M.
AU - Roberts, Christian K.
AU - Shaibi, Gabriel
AU - Lane, Christianne J.
AU - Higgins, Paul B.
AU - Davis, Jaimie N.
AU - Weigensberg, Marc J.
AU - Goran, Michael I.
N1 - Funding Information:
We would like to thank the staff of the University of Southern California/Los Angeles County GCRC and the dedicated SOLAR staff over the past six years. Our gratitude is also extended to the loyal participants and their families for their continued participation. This work is supported by NIDDK grants 3R01DK59211 (M.I. Goran) and General Clinical Research Center for Health Resources grant (M01 RR 00043). Claudia Toledo-Corral was supported by a minority supplement grant under the direction of M.I. Goran (3R01DK59211-06S1). Christian K. Roberts was supported during this project by a National Institute on Aging Training Award (5 T32 AG000093-24).
PY - 2008/9
Y1 - 2008/9
N2 - The purpose of this study was to examine interrelationships between IGF-I, IGF binding proteins (IGFBPs) and adiposity in 178 overweight Hispanic adolescents (11.2 ± 1.7 yr; body mass index: 28.2 ± 5.4 kg/m2). Immunoradiometric assays were used to measure IGF-I, IGFBP-1 and IGFBP-3. Total fat and lean tissue mass were measured by DEXA and visceral and subcutaneous adipose tissue by MRI. IGF-I and IGFBP-3 remained inversely correlated with total body fat mass (r = -0.52, p <0.001 and r = -0.25, p <0.01, respectively) after controlling for covariates. IGFBP-1 was inversely correlated to total fat mass (r = -0.55, p <0.001) in simple correlations; however, this relationship was eliminated after controlling for covariates (r = 0.02, p = 0.85). Correlations with visceral and subcutaneous adipose tissue yielded similar results. These results demonstrate that IGF-I, IGFBP-1 and IGFBP-3 are all inversely related to adiposity in Hispanic children.
AB - The purpose of this study was to examine interrelationships between IGF-I, IGF binding proteins (IGFBPs) and adiposity in 178 overweight Hispanic adolescents (11.2 ± 1.7 yr; body mass index: 28.2 ± 5.4 kg/m2). Immunoradiometric assays were used to measure IGF-I, IGFBP-1 and IGFBP-3. Total fat and lean tissue mass were measured by DEXA and visceral and subcutaneous adipose tissue by MRI. IGF-I and IGFBP-3 remained inversely correlated with total body fat mass (r = -0.52, p <0.001 and r = -0.25, p <0.01, respectively) after controlling for covariates. IGFBP-1 was inversely correlated to total fat mass (r = -0.55, p <0.001) in simple correlations; however, this relationship was eliminated after controlling for covariates (r = 0.02, p = 0.85). Correlations with visceral and subcutaneous adipose tissue yielded similar results. These results demonstrate that IGF-I, IGFBP-1 and IGFBP-3 are all inversely related to adiposity in Hispanic children.
KW - Children
KW - IGF
KW - IGFBP-1
KW - IGFBP-3
KW - Obesity
KW - Visceral fat
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U2 - 10.1515/JPEM.2008.21.9.855
DO - 10.1515/JPEM.2008.21.9.855
M3 - Article
C2 - 18924579
AN - SCOPUS:53849124323
SN - 0334-018X
VL - 21
SP - 855
EP - 864
JO - Journal of Pediatric Endocrinology and Metabolism
JF - Journal of Pediatric Endocrinology and Metabolism
IS - 9
ER -