Injury response checkpoint and developmental timing in insects

Jennifer Hackney Price, Peter Cherbas

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In insects, localized tissue injury often leads to global (organism-wide) delays in development and retarded metamorphosis. In Drosophila, for example, injuries to the larval imaginal discs can retard pupariation and prolong metamorphosis. Injuries induced by treatments such as radiation, mechanical damage and induction of localized cell death can trigger similar delays. In most cases, the duration of the developmental delay appears to be correlated with the extent of damage, but the effect is also sensitive to the developmental stage of the treated animal. The proximate cause of the delays is likely a disruption of the ecdysone signaling pathway, but the intermediate steps leading from tissue injury and/or regeneration to that disruption remain unknown. Here, we review the evidence for injury-induced developmental delays, and for a checkpoint or checkpoints associated with the temporal progression of development and the on-going efforts to define the mechanisms involved.

Original languageEnglish (US)
Pages (from-to)226-231
Number of pages6
JournalFly
Volume8
Issue number4
DOIs
StatePublished - Jan 1 2014

Fingerprint

metamorphosis
pupariation
imaginal discs
insects
ecdysone
mechanical damage
cell death
Drosophila
developmental stages
duration
organisms
animals
tissues

Keywords

  • Developmental Timing
  • Drosophila Development
  • Ecdysone
  • Injury
  • PTTH
  • Regeneration

ASJC Scopus subject areas

  • Insect Science

Cite this

Injury response checkpoint and developmental timing in insects. / Hackney Price, Jennifer; Cherbas, Peter.

In: Fly, Vol. 8, No. 4, 01.01.2014, p. 226-231.

Research output: Contribution to journalArticle

Hackney Price, Jennifer ; Cherbas, Peter. / Injury response checkpoint and developmental timing in insects. In: Fly. 2014 ; Vol. 8, No. 4. pp. 226-231.
@article{7489643d8df2470482e62ba181961ae3,
title = "Injury response checkpoint and developmental timing in insects",
abstract = "In insects, localized tissue injury often leads to global (organism-wide) delays in development and retarded metamorphosis. In Drosophila, for example, injuries to the larval imaginal discs can retard pupariation and prolong metamorphosis. Injuries induced by treatments such as radiation, mechanical damage and induction of localized cell death can trigger similar delays. In most cases, the duration of the developmental delay appears to be correlated with the extent of damage, but the effect is also sensitive to the developmental stage of the treated animal. The proximate cause of the delays is likely a disruption of the ecdysone signaling pathway, but the intermediate steps leading from tissue injury and/or regeneration to that disruption remain unknown. Here, we review the evidence for injury-induced developmental delays, and for a checkpoint or checkpoints associated with the temporal progression of development and the on-going efforts to define the mechanisms involved.",
keywords = "Developmental Timing, Drosophila Development, Ecdysone, Injury, PTTH, Regeneration",
author = "{Hackney Price}, Jennifer and Peter Cherbas",
year = "2014",
month = "1",
day = "1",
doi = "10.1080/19336934.2015.1034913",
language = "English (US)",
volume = "8",
pages = "226--231",
journal = "Fly",
issn = "1933-6934",
publisher = "Landes Bioscience",
number = "4",

}

TY - JOUR

T1 - Injury response checkpoint and developmental timing in insects

AU - Hackney Price, Jennifer

AU - Cherbas, Peter

PY - 2014/1/1

Y1 - 2014/1/1

N2 - In insects, localized tissue injury often leads to global (organism-wide) delays in development and retarded metamorphosis. In Drosophila, for example, injuries to the larval imaginal discs can retard pupariation and prolong metamorphosis. Injuries induced by treatments such as radiation, mechanical damage and induction of localized cell death can trigger similar delays. In most cases, the duration of the developmental delay appears to be correlated with the extent of damage, but the effect is also sensitive to the developmental stage of the treated animal. The proximate cause of the delays is likely a disruption of the ecdysone signaling pathway, but the intermediate steps leading from tissue injury and/or regeneration to that disruption remain unknown. Here, we review the evidence for injury-induced developmental delays, and for a checkpoint or checkpoints associated with the temporal progression of development and the on-going efforts to define the mechanisms involved.

AB - In insects, localized tissue injury often leads to global (organism-wide) delays in development and retarded metamorphosis. In Drosophila, for example, injuries to the larval imaginal discs can retard pupariation and prolong metamorphosis. Injuries induced by treatments such as radiation, mechanical damage and induction of localized cell death can trigger similar delays. In most cases, the duration of the developmental delay appears to be correlated with the extent of damage, but the effect is also sensitive to the developmental stage of the treated animal. The proximate cause of the delays is likely a disruption of the ecdysone signaling pathway, but the intermediate steps leading from tissue injury and/or regeneration to that disruption remain unknown. Here, we review the evidence for injury-induced developmental delays, and for a checkpoint or checkpoints associated with the temporal progression of development and the on-going efforts to define the mechanisms involved.

KW - Developmental Timing

KW - Drosophila Development

KW - Ecdysone

KW - Injury

KW - PTTH

KW - Regeneration

UR - http://www.scopus.com/inward/record.url?scp=84945185372&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84945185372&partnerID=8YFLogxK

U2 - 10.1080/19336934.2015.1034913

DO - 10.1080/19336934.2015.1034913

M3 - Article

C2 - 25833067

AN - SCOPUS:84945185372

VL - 8

SP - 226

EP - 231

JO - Fly

JF - Fly

SN - 1933-6934

IS - 4

ER -