Inhibitors of DNA Topoisomerase I Isolated from the Roots of Zanthoxylum nitidum

Sheng Ding Fang, Li Kai Wang, Sidney M. Hecht

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Abstract

A methanol extract of Zanthoxylum nitidum found to inhibit topoisomerase I-mediated DNA relaxation and stabilize the covalent binary complex between the enzyme and DNA was subjected to bioassay-guided fractionation; three strongly inhibitory principles were identified including nitidine, chelerythrine, and a new alkaloid for which the name isofagaridine is suggested.

Original languageEnglish (US)
Pages (from-to)5025-5027
Number of pages3
JournalJournal of Organic Chemistry
Volume58
Issue number19
DOIs
StatePublished - Sep 10 1993

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ASJC Scopus subject areas

  • Organic Chemistry

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