Inhibitors of DNA topoisomerase I isolated from the roots of Zanthoxylum nitidum

Sheng Ding Fang, Li Kai Wang, Sidney Hecht

Research output: Contribution to journalArticle

158 Citations (Scopus)

Abstract

A methanol extract of Zanthoxylum nitidum found to inhibit topoisomerase I-mediated DNA relaxation and stabilize the covalent binary complex between the enzyme and DNA was subjected to bioassay-guided fractionation; three strongly inhibitory principles were identified including nitidine, chelerythrine, and a new alkaloid for which the name isofagaridine is suggested.

Original languageEnglish (US)
Pages (from-to)5025-5027
Number of pages3
JournalJournal of Organic Chemistry
Volume58
Issue number19
StatePublished - 1993
Externally publishedYes

Fingerprint

Topoisomerase I Inhibitors
Type I DNA Topoisomerase
Bioassay
DNA
Fractionation
Alkaloids
Methanol
Enzymes
nitidine
chelerythrine

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Inhibitors of DNA topoisomerase I isolated from the roots of Zanthoxylum nitidum. / Fang, Sheng Ding; Wang, Li Kai; Hecht, Sidney.

In: Journal of Organic Chemistry, Vol. 58, No. 19, 1993, p. 5025-5027.

Research output: Contribution to journalArticle

@article{abb89b7935f14526955204983d9c81c7,
title = "Inhibitors of DNA topoisomerase I isolated from the roots of Zanthoxylum nitidum",
abstract = "A methanol extract of Zanthoxylum nitidum found to inhibit topoisomerase I-mediated DNA relaxation and stabilize the covalent binary complex between the enzyme and DNA was subjected to bioassay-guided fractionation; three strongly inhibitory principles were identified including nitidine, chelerythrine, and a new alkaloid for which the name isofagaridine is suggested.",
author = "Fang, {Sheng Ding} and Wang, {Li Kai} and Sidney Hecht",
year = "1993",
language = "English (US)",
volume = "58",
pages = "5025--5027",
journal = "Journal of Organic Chemistry",
issn = "0022-3263",
publisher = "American Chemical Society",
number = "19",

}

TY - JOUR

T1 - Inhibitors of DNA topoisomerase I isolated from the roots of Zanthoxylum nitidum

AU - Fang, Sheng Ding

AU - Wang, Li Kai

AU - Hecht, Sidney

PY - 1993

Y1 - 1993

N2 - A methanol extract of Zanthoxylum nitidum found to inhibit topoisomerase I-mediated DNA relaxation and stabilize the covalent binary complex between the enzyme and DNA was subjected to bioassay-guided fractionation; three strongly inhibitory principles were identified including nitidine, chelerythrine, and a new alkaloid for which the name isofagaridine is suggested.

AB - A methanol extract of Zanthoxylum nitidum found to inhibit topoisomerase I-mediated DNA relaxation and stabilize the covalent binary complex between the enzyme and DNA was subjected to bioassay-guided fractionation; three strongly inhibitory principles were identified including nitidine, chelerythrine, and a new alkaloid for which the name isofagaridine is suggested.

UR - http://www.scopus.com/inward/record.url?scp=0027451734&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027451734&partnerID=8YFLogxK

M3 - Article

VL - 58

SP - 5025

EP - 5027

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

SN - 0022-3263

IS - 19

ER -