Inhibitors of DNA Topoisomerase I Isolated from the Roots of Zanthoxylum nitidum

Sheng Ding Fang, Li Kai Wang, Sidney M. Hecht

Research output: Contribution to journalArticle

162 Scopus citations


A methanol extract of Zanthoxylum nitidum found to inhibit topoisomerase I-mediated DNA relaxation and stabilize the covalent binary complex between the enzyme and DNA was subjected to bioassay-guided fractionation; three strongly inhibitory principles were identified including nitidine, chelerythrine, and a new alkaloid for which the name isofagaridine is suggested.

Original languageEnglish (US)
Pages (from-to)5025-5027
Number of pages3
JournalJournal of Organic Chemistry
Issue number19
StatePublished - Sep 10 1993


ASJC Scopus subject areas

  • Organic Chemistry

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