Inhibitors of DNA Topoisomerase I Isolated from the Roots of Zanthoxylum nitidum

Sheng Ding Fang; Li Kai Wang; Sidney M. Hecht

doi:10.1021/jo00071a001

Inhibitors of DNA Topoisomerase I Isolated from the Roots of Zanthoxylum nitidum

Sheng Ding Fang, Li Kai Wang, Sidney M. Hecht

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178 Scopus citations

Abstract

A methanol extract of Zanthoxylum nitidum found to inhibit topoisomerase I-mediated DNA relaxation and stabilize the covalent binary complex between the enzyme and DNA was subjected to bioassay-guided fractionation; three strongly inhibitory principles were identified including nitidine, chelerythrine, and a new alkaloid for which the name isofagaridine is suggested.

Original language	English (US)
Pages (from-to)	5025-5027
Number of pages	3
Journal	Journal of Organic Chemistry
Volume	58
Issue number	19
DOIs	https://doi.org/10.1021/jo00071a001
State	Published - Sep 10 1993
Externally published	Yes

ASJC Scopus subject areas

Organic Chemistry

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title = "Inhibitors of DNA Topoisomerase I Isolated from the Roots of Zanthoxylum nitidum",

abstract = "A methanol extract of Zanthoxylum nitidum found to inhibit topoisomerase I-mediated DNA relaxation and stabilize the covalent binary complex between the enzyme and DNA was subjected to bioassay-guided fractionation; three strongly inhibitory principles were identified including nitidine, chelerythrine, and a new alkaloid for which the name isofagaridine is suggested.",

author = "Fang, {Sheng Ding} and Wang, {Li Kai} and Hecht, {Sidney M.}",

year = "1993",

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AB - A methanol extract of Zanthoxylum nitidum found to inhibit topoisomerase I-mediated DNA relaxation and stabilize the covalent binary complex between the enzyme and DNA was subjected to bioassay-guided fractionation; three strongly inhibitory principles were identified including nitidine, chelerythrine, and a new alkaloid for which the name isofagaridine is suggested.

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Inhibitors of DNA Topoisomerase I Isolated from the Roots of Zanthoxylum nitidum

Abstract

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