Inhibition of T suppressor cell expression by histamine type 2 (H2) receptor antagonists

D. E. Griswold, S. Alessi, A. M. Badger, G. Poste, N. Hanna

Research output: Contribution to journalArticle

84 Scopus citations

Abstract

The effect of histamine type 2 (H2) receptor antagonists, cimetidine and ranitidine, on the induction and expression of hapten-specific suppressor T cells was studied. The activity of DNBSO3-induced suppressor cells was evaluated after adoptive transfer to naive syngeneic recipients. Treatment with cimetidine or ranitidine markedly inhibited suppressor T cell activity in a dose-related manner and enhanced the contact sensitivity response to DNFB. Both H2 antagonists were effective in inhibiting the expression and, to a lesser extent, the induction of suppressor T cells. In contrast, norburimamide, a non-H2 antagonist structurally related to cimetidine, was inactive. The relevance of these findings to the clinical observation of cimetidine-induced reversal of acquired tolerance to dinitrochlorobenzene in anergic patients is discussed.

Original languageEnglish (US)
Pages (from-to)3054-3057
Number of pages4
JournalJournal of Immunology
Volume132
Issue number6
StatePublished - Jul 19 1984
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Griswold, D. E., Alessi, S., Badger, A. M., Poste, G., & Hanna, N. (1984). Inhibition of T suppressor cell expression by histamine type 2 (H2) receptor antagonists. Journal of Immunology, 132(6), 3054-3057.