Inhibition of T suppressor cell expression by histamine type 2 (H2) receptor antagonists

D. E. Griswold, S. Alessi, A. M. Badger, George Poste, N. Hanna

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

The effect of histamine type 2 (H2) receptor antagonists, cimetidine and ranitidine, on the induction and expression of hapten-specific suppressor T cells was studied. The activity of DNBSO3-induced suppressor cells was evaluated after adoptive transfer to naive syngeneic recipients. Treatment with cimetidine or ranitidine markedly inhibited suppressor T cell activity in a dose-related manner and enhanced the contact sensitivity response to DNFB. Both H2 antagonists were effective in inhibiting the expression and, to a lesser extent, the induction of suppressor T cells. In contrast, norburimamide, a non-H2 antagonist structurally related to cimetidine, was inactive. The relevance of these findings to the clinical observation of cimetidine-induced reversal of acquired tolerance to dinitrochlorobenzene in anergic patients is discussed.

Original languageEnglish (US)
Pages (from-to)3054-3057
Number of pages4
JournalJournal of Immunology
Volume132
Issue number6
StatePublished - 1984
Externally publishedYes

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Histamine Receptors
Cimetidine
Ranitidine
T-Lymphocytes
Dinitrofluorobenzene
Dinitrochlorobenzene
Adoptive Transfer
Haptens
Histamine Antagonists
Contact Dermatitis
Observation
Therapeutics

ASJC Scopus subject areas

  • Immunology

Cite this

Griswold, D. E., Alessi, S., Badger, A. M., Poste, G., & Hanna, N. (1984). Inhibition of T suppressor cell expression by histamine type 2 (H2) receptor antagonists. Journal of Immunology, 132(6), 3054-3057.

Inhibition of T suppressor cell expression by histamine type 2 (H2) receptor antagonists. / Griswold, D. E.; Alessi, S.; Badger, A. M.; Poste, George; Hanna, N.

In: Journal of Immunology, Vol. 132, No. 6, 1984, p. 3054-3057.

Research output: Contribution to journalArticle

Griswold, DE, Alessi, S, Badger, AM, Poste, G & Hanna, N 1984, 'Inhibition of T suppressor cell expression by histamine type 2 (H2) receptor antagonists', Journal of Immunology, vol. 132, no. 6, pp. 3054-3057.
Griswold, D. E. ; Alessi, S. ; Badger, A. M. ; Poste, George ; Hanna, N. / Inhibition of T suppressor cell expression by histamine type 2 (H2) receptor antagonists. In: Journal of Immunology. 1984 ; Vol. 132, No. 6. pp. 3054-3057.
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