In vivo activity of anprocide alone, and in vitro activity in combination with conventional antibiotics against Staphylococcus aureus and Staphylococcus epidermidis biofilms

Robin Pettit, Christine A. Weber, Stacey B. Lawrence, George Pettit, Melissa J. Kean, Gary D. Cage

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The alarming spread of multiple drug resistance in Staphylococcus aureus, combined with the frequent occurrence of S. aureus and Staphylococcus epidermidis in biofilm-type infections, indicates a growing need for new therapies. The experimental steroidal amide anprocide [3β-acetoxy-17β- (L-prolyl)amino-5α-androstane] significantly reduced c.f.u. ml -1 per suture (P <0.0001) in a murine model of topical S. aureus infection. In chequerboard assays with planktonic-grown S. aureus and S. epidermidis, anprocide was synergistic with bacitracin, oxacillin, clindamycin or ceftriaxone. Anprocide was also synergistic in combination with bacitracin or oxacillin against some isolates of biofilm-grown S. aureus and S. epidermidis.

Original languageEnglish (US)
Pages (from-to)1203-1206
Number of pages4
JournalJournal of Medical Microbiology
Volume58
Issue number9
DOIs
StatePublished - Sep 2009

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Staphylococcus epidermidis
Biofilms
Staphylococcus aureus
Anti-Bacterial Agents
Bacitracin
Oxacillin
Clindamycin
Ceftriaxone
Multiple Drug Resistance
Infection
Amides
Sutures
In Vitro Techniques
3-acetoxy-17-prolylaminoandrostane

ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology

Cite this

In vivo activity of anprocide alone, and in vitro activity in combination with conventional antibiotics against Staphylococcus aureus and Staphylococcus epidermidis biofilms. / Pettit, Robin; Weber, Christine A.; Lawrence, Stacey B.; Pettit, George; Kean, Melissa J.; Cage, Gary D.

In: Journal of Medical Microbiology, Vol. 58, No. 9, 09.2009, p. 1203-1206.

Research output: Contribution to journalArticle

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