In vitro and in silico study of intracranial stent treatments for cerebral aneurysms: Effects on perforating vessel flows

Breigh Nonte Roszelle, M. Haithem Babiker, Walter Hafner, L. Fernando Gonzalez, Felipe C. Albuquerque, David Frakes

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background Many cerebral aneurysms can be treated effectively with intracranial stents. Unfortunately, stents can occlude perforating vessels near the treatment site which can decrease cerebral perfusion and increase the risk of stroke. Methods Particle image velocimetry was used to investigate the effects of intracranial stents on flows in perforators near a treated aneurysm. In Phase 1 of the study, different stent configurations were deployed into an idealized physical model of a sidewall aneurysm with perforating vessels. The configurations investigated were the Pipeline embolization device (PED) and one, two and three telescoping Neuroform stents. In Phase 2 of the study a single Neuroform stent was deployed so that the stent struts directly occluded the perforating vessel. Results In Phase 1 of the study it was found that even three telescoping stents affected perforating vessel flow less than a single PED under pulsatile conditions (average reduction 32.7% vs 46.5%). Results from Phase 2 indicated that the location of the occluding strut across the perforating vessel orifice had a greater impact on perforating vessel flow than the percentage occlusion. Conclusion The findings of this study show that the use, configuration and positioning of intracranial stents can all have considerable influence on flow in affected perforating vessels near treated cerebral aneurysms.

Original languageEnglish (US)
Pages (from-to)354-360
Number of pages7
JournalJournal of NeuroInterventional Surgery
Volume5
Issue number4
DOIs
StatePublished - Jul 2013

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Intracranial Aneurysm
Computer Simulation
Stents
Telescopes
Aneurysm
In Vitro Techniques
Equipment and Supplies
Rheology
Perfusion
Stroke

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

In vitro and in silico study of intracranial stent treatments for cerebral aneurysms : Effects on perforating vessel flows. / Roszelle, Breigh Nonte; Haithem Babiker, M.; Hafner, Walter; Fernando Gonzalez, L.; Albuquerque, Felipe C.; Frakes, David.

In: Journal of NeuroInterventional Surgery, Vol. 5, No. 4, 07.2013, p. 354-360.

Research output: Contribution to journalArticle

Roszelle, Breigh Nonte ; Haithem Babiker, M. ; Hafner, Walter ; Fernando Gonzalez, L. ; Albuquerque, Felipe C. ; Frakes, David. / In vitro and in silico study of intracranial stent treatments for cerebral aneurysms : Effects on perforating vessel flows. In: Journal of NeuroInterventional Surgery. 2013 ; Vol. 5, No. 4. pp. 354-360.
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