In silico analysis suggests interaction between Ebola virus and the extracellular matrix

Veljko Veljkovic, Sanja Glisic, Claude P. Muller, Matthew Scotch, Donald R. Branch, Vladimir R. Perovic, Milan Sencanski, Nevena Veljkovic, Alfonso Colombatti

Research output: Contribution to journalArticle

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Abstract

The worst Ebola virus (EV) outbreak in history has hit Liberia, Sierra Leone and Guinea hardest and the trend lines in this crisis are grave, and now represents a global public health threat concern. Limited therapeutic and/or prophylactic options are available for people suffering from Ebola virus disease (EVD) and further complicate the situation. Previous studies suggested that the EV glycoprotein (GP) is the main determinant causing structural damage of endothelial cells that triggers the hemorrhagic diathesis, but molecular mechanisms underlying this phenomenon remains elusive. Using the informational spectrum method (ISM), a virtual spectroscopy method for analysis of the protein-protein interactions, the interaction of GP with endothelial extracellular matrix (ECM) was investigated. Presented results of this in silico study suggest that Elastin Microfibril Interface Located Proteins (EMILINs) are involved in interaction between GP and ECM. This finding could contribute to a better understanding of EV/endothelium interaction and its role in pathogenesis, prevention and therapy of EVD.

Original languageEnglish (US)
Article number135
JournalFrontiers in Microbiology
Volume6
Issue numberFEB
DOIs
StatePublished - 2015

Fingerprint

Ebolavirus
Ebola Hemorrhagic Fever
Computer Simulation
Extracellular Matrix
Glycoproteins
Liberia
Sierra Leone
Guinea
Hemorrhagic Disorders
Endothelium
Disease Outbreaks
Spectrum Analysis
Proteins
Endothelial Cells
Public Health
History
Therapeutics

Keywords

  • Ebola virus
  • EMILINs
  • Endothelial extracellular matrix
  • Glycoprotein GP
  • In silico analysis

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

Cite this

Veljkovic, V., Glisic, S., Muller, C. P., Scotch, M., Branch, D. R., Perovic, V. R., ... Colombatti, A. (2015). In silico analysis suggests interaction between Ebola virus and the extracellular matrix. Frontiers in Microbiology, 6(FEB), [135]. https://doi.org/10.3389/fmicb.2015.00135

In silico analysis suggests interaction between Ebola virus and the extracellular matrix. / Veljkovic, Veljko; Glisic, Sanja; Muller, Claude P.; Scotch, Matthew; Branch, Donald R.; Perovic, Vladimir R.; Sencanski, Milan; Veljkovic, Nevena; Colombatti, Alfonso.

In: Frontiers in Microbiology, Vol. 6, No. FEB, 135, 2015.

Research output: Contribution to journalArticle

Veljkovic, V, Glisic, S, Muller, CP, Scotch, M, Branch, DR, Perovic, VR, Sencanski, M, Veljkovic, N & Colombatti, A 2015, 'In silico analysis suggests interaction between Ebola virus and the extracellular matrix', Frontiers in Microbiology, vol. 6, no. FEB, 135. https://doi.org/10.3389/fmicb.2015.00135
Veljkovic, Veljko ; Glisic, Sanja ; Muller, Claude P. ; Scotch, Matthew ; Branch, Donald R. ; Perovic, Vladimir R. ; Sencanski, Milan ; Veljkovic, Nevena ; Colombatti, Alfonso. / In silico analysis suggests interaction between Ebola virus and the extracellular matrix. In: Frontiers in Microbiology. 2015 ; Vol. 6, No. FEB.
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