Improving international research with clinical specimens: 5 achievable objectives

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Our increased interest in translational research has created a large demand for blood, tissue, and other clinical samples, which find use in a broad variety of research including genomics, proteomics, and metabolomics. Hundreds of millions of dollars have been invested internationally on the collection, storage, and distribution of samples. Nevertheless, many researchers complain in frustration about their inability to obtain relevant and/or useful samples for their research. Lack of access to samples, poor condition of samples, and unavailability of appropriate control samples have slowed our progress in the study of diseases and biomarkers. In this perspective, I focus on five major challenges that thwart clinical sample use for translational research and propose near term objectives to address them. They include: (1) defining our biobanking needs; (2) increasing the use of and access to standard operating procedures; (3) mapping interobserver differences for use in normalizing diagnoses; (4) identifying natural internal protein controls; and (5) redefining the clinical sample paradigm by building partnerships with the public. In each case, I believe that we have the tools at hand required to achieve the objective within 5 years. Potential paths to achieve these objectives are explored. However we solve these problems, the future of proteomics depends on access to high quality clinical samples, collected under standardized conditions, accurately annotated and shared under conditions that promote the research we need to do.

Original languageEnglish (US)
Pages (from-to)5592-5601
Number of pages10
JournalJournal of Proteome Research
Volume11
Issue number12
DOIs
StatePublished - Dec 7 2012

Fingerprint

Translational Medical Research
Proteomics
Research
Frustration
Metabolomics
Genomics
Hand
Biomarkers
Research Personnel
Blood
Tissue
Proteins

Keywords

  • biobank
  • blood
  • calibration
  • case/control
  • clinical
  • cohort
  • database
  • disease
  • diversity
  • donors
  • ethics
  • governance
  • healthcare
  • inclusion
  • informed consent
  • proteomics
  • public partnership
  • reference standard
  • sample processing
  • specimen
  • standard operating procedure
  • standardization
  • tissue
  • translational

ASJC Scopus subject areas

  • Biochemistry
  • Chemistry(all)

Cite this

Improving international research with clinical specimens : 5 achievable objectives. / LaBaer, Joshua.

In: Journal of Proteome Research, Vol. 11, No. 12, 07.12.2012, p. 5592-5601.

Research output: Contribution to journalArticle

@article{77e0ccdc2ec54be0871c00ff6e8e139f,
title = "Improving international research with clinical specimens: 5 achievable objectives",
abstract = "Our increased interest in translational research has created a large demand for blood, tissue, and other clinical samples, which find use in a broad variety of research including genomics, proteomics, and metabolomics. Hundreds of millions of dollars have been invested internationally on the collection, storage, and distribution of samples. Nevertheless, many researchers complain in frustration about their inability to obtain relevant and/or useful samples for their research. Lack of access to samples, poor condition of samples, and unavailability of appropriate control samples have slowed our progress in the study of diseases and biomarkers. In this perspective, I focus on five major challenges that thwart clinical sample use for translational research and propose near term objectives to address them. They include: (1) defining our biobanking needs; (2) increasing the use of and access to standard operating procedures; (3) mapping interobserver differences for use in normalizing diagnoses; (4) identifying natural internal protein controls; and (5) redefining the clinical sample paradigm by building partnerships with the public. In each case, I believe that we have the tools at hand required to achieve the objective within 5 years. Potential paths to achieve these objectives are explored. However we solve these problems, the future of proteomics depends on access to high quality clinical samples, collected under standardized conditions, accurately annotated and shared under conditions that promote the research we need to do.",
keywords = "biobank, blood, calibration, case/control, clinical, cohort, database, disease, diversity, donors, ethics, governance, healthcare, inclusion, informed consent, proteomics, public partnership, reference standard, sample processing, specimen, standard operating procedure, standardization, tissue, translational",
author = "Joshua LaBaer",
year = "2012",
month = "12",
day = "7",
doi = "10.1021/pr300796m",
language = "English (US)",
volume = "11",
pages = "5592--5601",
journal = "Journal of Proteome Research",
issn = "1535-3893",
publisher = "American Chemical Society",
number = "12",

}

TY - JOUR

T1 - Improving international research with clinical specimens

T2 - 5 achievable objectives

AU - LaBaer, Joshua

PY - 2012/12/7

Y1 - 2012/12/7

N2 - Our increased interest in translational research has created a large demand for blood, tissue, and other clinical samples, which find use in a broad variety of research including genomics, proteomics, and metabolomics. Hundreds of millions of dollars have been invested internationally on the collection, storage, and distribution of samples. Nevertheless, many researchers complain in frustration about their inability to obtain relevant and/or useful samples for their research. Lack of access to samples, poor condition of samples, and unavailability of appropriate control samples have slowed our progress in the study of diseases and biomarkers. In this perspective, I focus on five major challenges that thwart clinical sample use for translational research and propose near term objectives to address them. They include: (1) defining our biobanking needs; (2) increasing the use of and access to standard operating procedures; (3) mapping interobserver differences for use in normalizing diagnoses; (4) identifying natural internal protein controls; and (5) redefining the clinical sample paradigm by building partnerships with the public. In each case, I believe that we have the tools at hand required to achieve the objective within 5 years. Potential paths to achieve these objectives are explored. However we solve these problems, the future of proteomics depends on access to high quality clinical samples, collected under standardized conditions, accurately annotated and shared under conditions that promote the research we need to do.

AB - Our increased interest in translational research has created a large demand for blood, tissue, and other clinical samples, which find use in a broad variety of research including genomics, proteomics, and metabolomics. Hundreds of millions of dollars have been invested internationally on the collection, storage, and distribution of samples. Nevertheless, many researchers complain in frustration about their inability to obtain relevant and/or useful samples for their research. Lack of access to samples, poor condition of samples, and unavailability of appropriate control samples have slowed our progress in the study of diseases and biomarkers. In this perspective, I focus on five major challenges that thwart clinical sample use for translational research and propose near term objectives to address them. They include: (1) defining our biobanking needs; (2) increasing the use of and access to standard operating procedures; (3) mapping interobserver differences for use in normalizing diagnoses; (4) identifying natural internal protein controls; and (5) redefining the clinical sample paradigm by building partnerships with the public. In each case, I believe that we have the tools at hand required to achieve the objective within 5 years. Potential paths to achieve these objectives are explored. However we solve these problems, the future of proteomics depends on access to high quality clinical samples, collected under standardized conditions, accurately annotated and shared under conditions that promote the research we need to do.

KW - biobank

KW - blood

KW - calibration

KW - case/control

KW - clinical

KW - cohort

KW - database

KW - disease

KW - diversity

KW - donors

KW - ethics

KW - governance

KW - healthcare

KW - inclusion

KW - informed consent

KW - proteomics

KW - public partnership

KW - reference standard

KW - sample processing

KW - specimen

KW - standard operating procedure

KW - standardization

KW - tissue

KW - translational

UR - http://www.scopus.com/inward/record.url?scp=84870889596&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84870889596&partnerID=8YFLogxK

U2 - 10.1021/pr300796m

DO - 10.1021/pr300796m

M3 - Article

C2 - 22998582

AN - SCOPUS:84870889596

VL - 11

SP - 5592

EP - 5601

JO - Journal of Proteome Research

JF - Journal of Proteome Research

SN - 1535-3893

IS - 12

ER -