Improved Viability of Chronic Neural Implants Using Thin Microelectrodes

P. J. Stice, A. Panitch, Jitendran Muthuswamy

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

The recording interface between neurons and an implanted microelectrode recording site is often compromised due to gliosis, rendering the implant non-functional under chronic conditions. The objective of this project is to design novel microelectrodes that will minimize gliosis under chronic implantation. We test the hypothesis that gliosis can be minimized or eliminated by reducing the cross-sectional area of the chronic implant. Current microelectrodes for recording chronic action potentials range from 25 μm to 100 μm or more in diameter. We fabricated neural implants by coating 12μm stainless steel microwires with poly-glycolic acid (PGA), a biodegradable polymer, resulting in a final diameter of 25μm. Twelve rats were implanted with the PGA coated electrode on the left hemisphere in the somatosensory cortex and with the regular 25 μm stainless microelectrode in the right hemisphere. The rat brains were perfused at 4 weeks after implantation and stained for glial fibrilliary acidic protein (GFAP) and microtubule associated protein-2 (MAP-2). The microelectrodes coated with PGA produced minimal gliosis compared to the conventional 25 μm wire and other silicon based microelectrodes. We conclude that ultra-thin neural implants with minimum cross-sectional area coated with PGA will greatly improve the functionality of microelectrodes under chronic conditions.

Original languageEnglish (US)
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
EditorsR.S. Leder
Pages1987-1989
Number of pages3
Volume2
StatePublished - 2003
EventA New Beginning for Human Health: Proceddings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Cancun, Mexico
Duration: Sep 17 2003Sep 21 2003

Other

OtherA New Beginning for Human Health: Proceddings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
CountryMexico
CityCancun
Period9/17/039/21/03

Fingerprint

glycolic acid
Microelectrodes
Acids
Rats
Proteins
Biodegradable polymers
Microtubule-Associated Proteins
Stainless Steel
Silicon
Neurons
Brain
Stainless steel
Wire
Coatings
Electrodes

Keywords

  • Chronic implants
  • Microelectrodes
  • Neural prostheses
  • Single-unit recording

ASJC Scopus subject areas

  • Bioengineering

Cite this

Stice, P. J., Panitch, A., & Muthuswamy, J. (2003). Improved Viability of Chronic Neural Implants Using Thin Microelectrodes. In R. S. Leder (Ed.), Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (Vol. 2, pp. 1987-1989)

Improved Viability of Chronic Neural Implants Using Thin Microelectrodes. / Stice, P. J.; Panitch, A.; Muthuswamy, Jitendran.

Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. ed. / R.S. Leder. Vol. 2 2003. p. 1987-1989.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Stice, PJ, Panitch, A & Muthuswamy, J 2003, Improved Viability of Chronic Neural Implants Using Thin Microelectrodes. in RS Leder (ed.), Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. vol. 2, pp. 1987-1989, A New Beginning for Human Health: Proceddings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Cancun, Mexico, 9/17/03.
Stice PJ, Panitch A, Muthuswamy J. Improved Viability of Chronic Neural Implants Using Thin Microelectrodes. In Leder RS, editor, Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 2. 2003. p. 1987-1989
Stice, P. J. ; Panitch, A. ; Muthuswamy, Jitendran. / Improved Viability of Chronic Neural Implants Using Thin Microelectrodes. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. editor / R.S. Leder. Vol. 2 2003. pp. 1987-1989
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