Immune Checkpoints of the B7 Family. Part 2. Representatives of the B7 Family B7-H3, B7-H4, B7-H5, B7-H6, B7-H7, and ILDR2 and Their Receptors

A. I. Chapoval, S. P. Chapoval, N. S. Shcherbakova, D. N. Shcherbakov

Research output: Contribution to journalReview article

Abstract

Abstract: Immune checkpoints regulate polarity, strength, and termination of the immune response. The leading roles in these processes are played by molecules of the B7 family. Based on data obtained using first representatives of the B7 family molecules, a two-signal model for T cells activation was proposed. The discovery of new homologues of B7-1 and B7-2 molecules revealed not only a great variety of their structural organization, but also new functions, for example the B7-H6 molecule is able to activate NK cells through interaction with NKp30 molecule. Manipulations of the B7 ligands and their interactions with specific receptors provide opportunities for fine tuning of the immune response against various pathogens and development of new drugs. The second part of this review provides information on recently discovered representatives of the B7 family, such as B7-H3, B7-H4, B7-H5, B7-H6, B7-H7, ILDR2, and their receptors.

Original languageEnglish (US)
Pages (from-to)321-334
Number of pages14
JournalRussian Journal of Bioorganic Chemistry
Volume45
Issue number5
DOIs
StatePublished - Sep 1 2019

Fingerprint

B7 Antigens
Molecules
T-cells
Pathogens
Cell Communication
Natural Killer Cells
Tuning
Chemical activation
Ligands
T-Lymphocytes
Pharmaceutical Preparations

Keywords

  • immune checkpoint molecules
  • immunotherapy
  • T-lymphocytes
  • the APC ligands
  • the B7 family

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry

Cite this

Immune Checkpoints of the B7 Family. Part 2. Representatives of the B7 Family B7-H3, B7-H4, B7-H5, B7-H6, B7-H7, and ILDR2 and Their Receptors. / Chapoval, A. I.; Chapoval, S. P.; Shcherbakova, N. S.; Shcherbakov, D. N.

In: Russian Journal of Bioorganic Chemistry, Vol. 45, No. 5, 01.09.2019, p. 321-334.

Research output: Contribution to journalReview article

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