Identification of two common variants contributing to serum apolipoprotein B levels in mexicans

Daphna Weissglas-Volkov, Christopher Plaisier, Adriana Huertas-Vazquez, Ivette Cruz-Bautista, Daniela Riaño-Barros, Miguel Herrera-Hernandez, Laura Riba, Rita M. Cantor, Janet S. Sinsheimer, Carlos A. Aguilar-Salinas, Teresa Tusie-Luna, Päivi Pajukanta

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE-: Although the Mexican population has a high predisposition to dyslipidemias and premature coronary artery disease, this population is underinvestigated for the genetic factors conferring the high susceptibility. This study attempted to determine these genetic factors. METHODS AND RESULTS-: First, we investigated apolipoprotein B (apoB) levels in Mexican extended families with familial combined hyperlipidemia using a two-step testing strategy. In the screening step, we screened 5721 single-nucleotide polymorphisms (SNPs) for linkage signals with apoB. In the test step, we analyzed the 130 SNPs residing in regions of suggestive linkage signals for association with apoB. We identified significant associations with two SNPs (ie, rs1424032 [P=6.07×10] and rs1349411 [P=2.72×10]) that surpassed the significance level for the number of tests performed in the test step (P<3.84×10). Second, these SNPs were tested for replication in Mexican hyperlipidemic case-control samples. The same risk alleles as in the families with familial combined hyperlipidemia were significantly associated (P<0.05) with apoB in the case-control samples. The rs1349411 resides near the apoB messenger RNA editing enzyme (APOBEC1) involved in the processing of APOB messenger RNA in the small intestine. The rs1424032 resides in a highly conserved noncoding region predicted to function as a regulatory element. CONCLUSION-: We identified two novel variants, rs1349411 and rs1424032, for serum apoB levels in Mexicans.

Original languageEnglish (US)
Pages (from-to)353-359
Number of pages7
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume30
Issue number2
DOIs
StatePublished - Feb 1 2010
Externally publishedYes

Fingerprint

Apolipoproteins B
Single Nucleotide Polymorphism
Familial Combined Hyperlipidemia
Serum
Exercise Test
RNA Editing
Dyslipidemias
Population
Small Intestine
Coronary Artery Disease
Alleles
Messenger RNA
Enzymes

Keywords

  • Apolipoproteins
  • Association
  • Cardiovascular disease
  • Lipids
  • Mexican population

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Weissglas-Volkov, D., Plaisier, C., Huertas-Vazquez, A., Cruz-Bautista, I., Riaño-Barros, D., Herrera-Hernandez, M., ... Pajukanta, P. (2010). Identification of two common variants contributing to serum apolipoprotein B levels in mexicans. Arteriosclerosis, Thrombosis, and Vascular Biology, 30(2), 353-359. https://doi.org/10.1161/ATVBAHA.109.196402

Identification of two common variants contributing to serum apolipoprotein B levels in mexicans. / Weissglas-Volkov, Daphna; Plaisier, Christopher; Huertas-Vazquez, Adriana; Cruz-Bautista, Ivette; Riaño-Barros, Daniela; Herrera-Hernandez, Miguel; Riba, Laura; Cantor, Rita M.; Sinsheimer, Janet S.; Aguilar-Salinas, Carlos A.; Tusie-Luna, Teresa; Pajukanta, Päivi.

In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 30, No. 2, 01.02.2010, p. 353-359.

Research output: Contribution to journalArticle

Weissglas-Volkov, D, Plaisier, C, Huertas-Vazquez, A, Cruz-Bautista, I, Riaño-Barros, D, Herrera-Hernandez, M, Riba, L, Cantor, RM, Sinsheimer, JS, Aguilar-Salinas, CA, Tusie-Luna, T & Pajukanta, P 2010, 'Identification of two common variants contributing to serum apolipoprotein B levels in mexicans', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 30, no. 2, pp. 353-359. https://doi.org/10.1161/ATVBAHA.109.196402
Weissglas-Volkov, Daphna ; Plaisier, Christopher ; Huertas-Vazquez, Adriana ; Cruz-Bautista, Ivette ; Riaño-Barros, Daniela ; Herrera-Hernandez, Miguel ; Riba, Laura ; Cantor, Rita M. ; Sinsheimer, Janet S. ; Aguilar-Salinas, Carlos A. ; Tusie-Luna, Teresa ; Pajukanta, Päivi. / Identification of two common variants contributing to serum apolipoprotein B levels in mexicans. In: Arteriosclerosis, Thrombosis, and Vascular Biology. 2010 ; Vol. 30, No. 2. pp. 353-359.
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AU - Riaño-Barros, Daniela

AU - Herrera-Hernandez, Miguel

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AU - Cantor, Rita M.

AU - Sinsheimer, Janet S.

AU - Aguilar-Salinas, Carlos A.

AU - Tusie-Luna, Teresa

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N2 - BACKGROUND AND PURPOSE-: Although the Mexican population has a high predisposition to dyslipidemias and premature coronary artery disease, this population is underinvestigated for the genetic factors conferring the high susceptibility. This study attempted to determine these genetic factors. METHODS AND RESULTS-: First, we investigated apolipoprotein B (apoB) levels in Mexican extended families with familial combined hyperlipidemia using a two-step testing strategy. In the screening step, we screened 5721 single-nucleotide polymorphisms (SNPs) for linkage signals with apoB. In the test step, we analyzed the 130 SNPs residing in regions of suggestive linkage signals for association with apoB. We identified significant associations with two SNPs (ie, rs1424032 [P=6.07×10] and rs1349411 [P=2.72×10]) that surpassed the significance level for the number of tests performed in the test step (P<3.84×10). Second, these SNPs were tested for replication in Mexican hyperlipidemic case-control samples. The same risk alleles as in the families with familial combined hyperlipidemia were significantly associated (P<0.05) with apoB in the case-control samples. The rs1349411 resides near the apoB messenger RNA editing enzyme (APOBEC1) involved in the processing of APOB messenger RNA in the small intestine. The rs1424032 resides in a highly conserved noncoding region predicted to function as a regulatory element. CONCLUSION-: We identified two novel variants, rs1349411 and rs1424032, for serum apoB levels in Mexicans.

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