Identification of inbred mouse strains harboring genetic modifiers of mammary tumor age of onset and metastatic progression

Traci Lifsted, Thomas Le Voyer, Max Williams, William Muller, Andres Klein-Szanto, Kenneth H. Buetow, Kent W. Hunter

Research output: Contribution to journalArticle

167 Scopus citations

Abstract

Metastasis is one of the most important and complex processes in human neoplastic disease. A large number of both positive and negative events must occur to permit a tumor cell to colonize a distant site successfully. To identify mouse strains that harbor dominant genetic modifiers of this process, a strain survey was initiated utilizing a transgenic mouse mammary tumor model that exhibits a high incidence of pulmonary metastases. The transgenic animal was bred to 27 different inbred strains of mice and scored for the metastatic organ tropism and metastatic density. Thirteen strains were identified that had a statistically significant reduction in the numbers of pulmonary metastases. In addition, 10 strains were identified that altered the kinetics of induction of the primary mammary tumor. These strains will likely provide useful model systems for the analysis of genetic interactions in the initiation and progression of mammary adenocarcinomas.

Original languageEnglish (US)
Pages (from-to)640-644
Number of pages5
JournalInternational Journal of Cancer
Volume77
Issue number4
DOIs
StatePublished - Jan 1 1998
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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