Helminth infection, fecundity, and age of first pregnancy in women

Aaron D. Blackwell, Marilyne A. Tamayo, Bret Beheim, Benjamin Trumble, Jonathan Stieglitz, Paul L. Hooper, Melanie Martin, Hillard Kaplan, Michael Gurven

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Infection with intestinal helminths results in immunological changes that influence co-infections, and might influence fecundity by inducing immunological states affecting conception and pregnancy.We investigated associations between intestinal helminths and fertility in women, using 9 years of longitudinal data from 986 Bolivian forager-horticulturalists, experiencing natural fertility and 70% helminth prevalence.We found that different species of helminth are associated with contrasting effects on fecundity. Infection with roundworm (Ascaris lumbricoides) is associated with earlier first births and shortened interbirth intervals, whereas infection with hookworm is associated with delayed first pregnancy and extended interbirth intervals. Thus, helminths may have important effects on human fertility that reflect physiological and immunological consequences of infection.

Original languageEnglish (US)
Pages (from-to)970-972
Number of pages3
JournalScience
Volume350
Issue number6263
DOIs
StatePublished - Nov 20 2015

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Helminths
Fertility
Pregnancy
Infection
Hookworm Infections
Ascaris lumbricoides
Birth Order
Coinfection

ASJC Scopus subject areas

  • Medicine(all)
  • General

Cite this

Blackwell, A. D., Tamayo, M. A., Beheim, B., Trumble, B., Stieglitz, J., Hooper, P. L., ... Gurven, M. (2015). Helminth infection, fecundity, and age of first pregnancy in women. Science, 350(6263), 970-972. https://doi.org/10.1126/science.aac7902

Helminth infection, fecundity, and age of first pregnancy in women. / Blackwell, Aaron D.; Tamayo, Marilyne A.; Beheim, Bret; Trumble, Benjamin; Stieglitz, Jonathan; Hooper, Paul L.; Martin, Melanie; Kaplan, Hillard; Gurven, Michael.

In: Science, Vol. 350, No. 6263, 20.11.2015, p. 970-972.

Research output: Contribution to journalArticle

Blackwell, AD, Tamayo, MA, Beheim, B, Trumble, B, Stieglitz, J, Hooper, PL, Martin, M, Kaplan, H & Gurven, M 2015, 'Helminth infection, fecundity, and age of first pregnancy in women', Science, vol. 350, no. 6263, pp. 970-972. https://doi.org/10.1126/science.aac7902
Blackwell AD, Tamayo MA, Beheim B, Trumble B, Stieglitz J, Hooper PL et al. Helminth infection, fecundity, and age of first pregnancy in women. Science. 2015 Nov 20;350(6263):970-972. https://doi.org/10.1126/science.aac7902
Blackwell, Aaron D. ; Tamayo, Marilyne A. ; Beheim, Bret ; Trumble, Benjamin ; Stieglitz, Jonathan ; Hooper, Paul L. ; Martin, Melanie ; Kaplan, Hillard ; Gurven, Michael. / Helminth infection, fecundity, and age of first pregnancy in women. In: Science. 2015 ; Vol. 350, No. 6263. pp. 970-972.
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