Glial cell and fibroblast cytotoxicity study on plasma-deposited diamond-like carbon coatings

Amarjit Singh, Gholamreza Ehteshami, Stephen Massia, Jiping He, Robin G. Storer, Gregory Raupp

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

Diamond-like carbon films have been evaluated as coatings to improve biocompatibility of orthopedic and cardiovascular implants. This study initiates a series of investigations that will evaluate diamond-like carbon (DLC) as a coating for improved biocompatibility in chronic neuroprosthetic implants. Studies in this report assess the cytotoxicity and cell adhesion behavior of DLC coatings exposed to glial and fibroblast cell lines in vitro. It can be concluded from these studies that DLC coatings do not adversely affect 3T3 fibroblast and T98-G glial cell function in vitro. We also successfully rendered DLC coatings non-adhesive (no significant fibroblast or glial cell adhesion) with surface immobilized dextran using methods developed for other biomaterials and applications. Future work will further develop DLC coatings on prototype microelectrode devices for chronic neural implant applications.

Original languageEnglish (US)
Pages (from-to)5083-5089
Number of pages7
JournalBiomaterials
Volume24
Issue number28
DOIs
StatePublished - Dec 2003

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Keywords

  • Cell-resistant surface
  • Diamond-like carbon films
  • Immobilized dextran
  • Neural prosthetics
  • Surface modification

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

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