GLEE--a model-driven execution system for computer-based implementation of clinical practice guidelines.

We have developed the GLEE system for execution of guidelines encoded in the GLIF3 format. This system can be integrated with a local clinical information system through standard interfaces to EMRs and clinical applications. The execution model of GLEE takes the "system suggests, user controls" approach. A tracing system is used to record the state of guideline steps and their transitions. GLEE provides an internal event-driven execution model that can be hooked up with the clinical event monitor in a local environment. We discuss the execution flexibility provided by GLEE and issues related to its integration in a local environment. Potential use of GLEE includes clinical decision support, quality assurance, guideline development and medical education.