Genetically guided engineering of human liver tissue from pluripotent stem cells

Mohammad Ebrahimkhani, Jeremy Velzaquez, Ryan Legraw, Farzaneh Moghadam, Jacquelyn Kilbourne, Samira Kiani

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose / Introduction: Mammalian tissue development is a multifaceted process of self-organization that emerges from gene regulatory networks of differentiating stem cells and their progenies. Stem cell derived organoids have shown high potentials to decode fundamental aspects of development while providing a platform for disease modeling and regenerative therapies. Current approaches to generate such cellular systems rely on recapitulating the developmental stages by supplementing growth factors or combining subset of cells. We propose a novel strategy to engineer selfvascularizing organoids via genetic engineering of developmental processes.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - Jan 1 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

Fingerprint

Organoids
Pluripotent Stem Cells
Human Engineering
Stem cells
Liver
Stem Cells
Tissue
Genetic engineering
Genetic Engineering
Gene Regulatory Networks
Intercellular Signaling Peptides and Proteins
Genes
Engineers
Therapeutics

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

Cite this

Ebrahimkhani, M., Velzaquez, J., Legraw, R., Moghadam, F., Kilbourne, J., & Kiani, S. (2019). Genetically guided engineering of human liver tissue from pluripotent stem cells. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40). Society for Biomaterials.

Genetically guided engineering of human liver tissue from pluripotent stem cells. / Ebrahimkhani, Mohammad; Velzaquez, Jeremy; Legraw, Ryan; Moghadam, Farzaneh; Kilbourne, Jacquelyn; Kiani, Samira.

Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Ebrahimkhani, M, Velzaquez, J, Legraw, R, Moghadam, F, Kilbourne, J & Kiani, S 2019, Genetically guided engineering of human liver tissue from pluripotent stem cells. in Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium, vol. 40, Society for Biomaterials, 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence, Seattle, United States, 4/3/19.
Ebrahimkhani M, Velzaquez J, Legraw R, Moghadam F, Kilbourne J, Kiani S. Genetically guided engineering of human liver tissue from pluripotent stem cells. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials. 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium).
Ebrahimkhani, Mohammad ; Velzaquez, Jeremy ; Legraw, Ryan ; Moghadam, Farzaneh ; Kilbourne, Jacquelyn ; Kiani, Samira. / Genetically guided engineering of human liver tissue from pluripotent stem cells. Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium).
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