TY - JOUR
T1 - Genetic moderation of the effects of the Family Check-Up intervention on children's internalizing symptoms
T2 - A longitudinal study with a racially/ethnically diverse sample
AU - Lemery, Kathryn
AU - Clifford, Sierra
AU - Dishion, Thomas J.
AU - Shaw, Daniel S.
AU - Wilson, Melvin N.
N1 - Funding Information:
Causadias José M. Cicchetti Dante Editors Lemery-Chalfant Kathryn a Clifford Sierra a Dishion Thomas J. a Shaw Daniel S. b Wilson Melvin N. c a Arizona State University b University of Pittsburgh c University of Virginia This research was supported by National Institute on Drug Abuse Grants DA022773, DA023245, and DA036832. Special thanks to the staff and students for their dedication to the Early Steps Multisite Study, and the participating families who generously shared their experiences. Address correspondence and reprint requests to: Kathryn Lemery-Chalfant, Department of Psychology , P.O. Box 871104 , Arizona State University , Tempe , AZ 85287 ; E-mail: klemery@asu.edu . 19 11 2018 12 2018 30 5
Publisher Copyright:
© Copyright Cambridge University Press 2018.
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Development involves synergistic interplay among genotypes and the physical and cultural environments, and integrating genetics into experimental designs that manipulate the environment can improve understanding of developmental psychopathology and intervention efficacy. Consistent with differential susceptibility theory, individuals can vary in their sensitivity to environmental conditions including intervention for reasons including their genotype. As a consequence, understanding genetic influences on intervention response is critical. Empirically, we tested an interaction between a genetic index representing sensitivity to the environment and the Family Check-Up intervention. Participants were drawn from the Early Steps Multisite randomized prevention trial that included a low-income and racially/ethnically diverse sample of children and their families followed longitudinally (n = 515). As hypothesized, polygenic sensitivity to the environment moderated the effects of the intervention on 10-year-old children's symptoms of internalizing psychopathology, such that children who were genetically sensitive and were randomly assigned to the intervention had fewer symptoms of child psychopathology than genetically sensitive children assigned to the control condition. A significant difference in internalizing symptoms assessed with a clinical interview emerged between the intervention and control groups for those 0.493 SD above the mean on polygenic sensitivity, or 25% of the sample. Similar to personalized medicine, it is time to understand individual and sociocultural differences in treatment response and individualize psychosocial interventions to reduce the burden of child psychopathology and maximize well-being for children growing up in a wide range of physical environments and cultures.
AB - Development involves synergistic interplay among genotypes and the physical and cultural environments, and integrating genetics into experimental designs that manipulate the environment can improve understanding of developmental psychopathology and intervention efficacy. Consistent with differential susceptibility theory, individuals can vary in their sensitivity to environmental conditions including intervention for reasons including their genotype. As a consequence, understanding genetic influences on intervention response is critical. Empirically, we tested an interaction between a genetic index representing sensitivity to the environment and the Family Check-Up intervention. Participants were drawn from the Early Steps Multisite randomized prevention trial that included a low-income and racially/ethnically diverse sample of children and their families followed longitudinally (n = 515). As hypothesized, polygenic sensitivity to the environment moderated the effects of the intervention on 10-year-old children's symptoms of internalizing psychopathology, such that children who were genetically sensitive and were randomly assigned to the intervention had fewer symptoms of child psychopathology than genetically sensitive children assigned to the control condition. A significant difference in internalizing symptoms assessed with a clinical interview emerged between the intervention and control groups for those 0.493 SD above the mean on polygenic sensitivity, or 25% of the sample. Similar to personalized medicine, it is time to understand individual and sociocultural differences in treatment response and individualize psychosocial interventions to reduce the burden of child psychopathology and maximize well-being for children growing up in a wide range of physical environments and cultures.
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U2 - 10.1017/S095457941800127X
DO - 10.1017/S095457941800127X
M3 - Article
C2 - 30451141
AN - SCOPUS:85056691802
SN - 0954-5794
VL - 30
SP - 1729
EP - 1747
JO - Development and psychopathology
JF - Development and psychopathology
IS - 5
ER -