Genetic marker study of dentinogenesis imperfecta.

M. G. Crall, C. F. Schuler, Kenneth Buetow, J. C. Murray

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

DGI-II has been linked to the group specific component (Gc) on 4q and to interferon induced protein 10 (INP10) on 4q. We studied a three generation family with DGI-II along with a four generation DGI-II family to more precisely place DGI-II in the existing genetic map of 4q and to determine if genetic heterogeneity existed between various DGI-II families. Affected family members had brownish discoloration of the teeth, enamel fracturing and radiographic evidence of coronal and radicular pulp chamber obliteration. Thirteen polymorphic markers on 4q were studied including D4S35, D4S1, ALB, Gc, MGSA, AR, INP10, ADH3, FGFB, EGF, IL2, IF, and MNS. Gc and MNS blood group antigen typing were done using commercial SERA. Restriction fragment length polymorphism analysis using Southern blotting was done on the remaining markers. Pairwise linkage analysis was performed using the procedures of Morton. Tight linkage between DGI-II and eleven genetic markers, including Gc and EGF, was excluded. The tightest linkage with DGI-II was identified with the probe INP10 at theta = 0.0 with lod = +3.91. However, INP10 RFLP differences were detected between the families, such that DGI-II correlated with different alleles in each family. Results from this study demonstrated that DGI-II may possibly arise from more than one genetic mutation.

Original languageEnglish (US)
Pages (from-to)285-293
Number of pages9
JournalProceedings of the Finnish Dental Society. Suomen Hammaslaakariseuran toimituksia
Volume88 Suppl 1
StatePublished - 1992
Externally publishedYes

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Dentinogenesis Imperfecta
Genetic Markers
Epidermal Growth Factor
Restriction Fragment Length Polymorphisms
Tooth Discoloration
Proteins
Genetic Heterogeneity
Dental Pulp Cavity
Dental Enamel
Blood Group Antigens
Southern Blotting
Interferons
Interleukin-2
Alleles
Mutation

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Genetic marker study of dentinogenesis imperfecta. / Crall, M. G.; Schuler, C. F.; Buetow, Kenneth; Murray, J. C.

In: Proceedings of the Finnish Dental Society. Suomen Hammaslaakariseuran toimituksia, Vol. 88 Suppl 1, 1992, p. 285-293.

Research output: Contribution to journalArticle

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