From the bench to the field in low-cost diagnostics: Two case studies

Ashok A. Kumar, Jonathan W. Hennek, Barbara Smith, Shailendra Kumar, Patrick Beattie, Sidhartha Jain, Jason P. Rolland, Thomas P. Stossel, Catherine Chunda-Liyoka, George M. Whitesides

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Despite the growth of research in universities on point-of-care (POC) diagnostics for global health, most devices never leave the laboratory. The processes that move diagnostic technology from the laboratory to the field - the processes intended to evaluate operation and performance under realistic conditions - are more complicated than they might seem. Two case studies illustrate this process: the development of a paper-based device to measure liver function, and the development of a device to identify sickle cell disease based on aqueous multiphase systems (AMPS) and differences in the densities of normal and sickled cells. Details of developing these devices provide strategies for forming partnerships, prototyping devices, designing studies, and evaluating POC diagnostics. Technical and procedural lessons drawn from these experiences may be useful to those designing diagnostic tests for developing countries, and more generally, technologies for use in resource-limited environments.

Original languageEnglish (US)
Pages (from-to)5836-5853
Number of pages18
JournalAngewandte Chemie - International Edition
Volume54
Issue number20
DOIs
StatePublished - May 11 2015
Externally publishedYes

Fingerprint

Costs and Cost Analysis
Equipment and Supplies
Point-of-Care Systems
Developing countries
Liver
Costs
Health
Technology
Sickle Cell Anemia
Routine Diagnostic Tests
Developing Countries
Growth
Research

Keywords

  • field trials
  • liver injury
  • point-of-care diagnostics
  • sickle cell disease
  • technologytranslation

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Medicine(all)

Cite this

Kumar, A. A., Hennek, J. W., Smith, B., Kumar, S., Beattie, P., Jain, S., ... Whitesides, G. M. (2015). From the bench to the field in low-cost diagnostics: Two case studies. Angewandte Chemie - International Edition, 54(20), 5836-5853. https://doi.org/10.1002/anie.201411741

From the bench to the field in low-cost diagnostics : Two case studies. / Kumar, Ashok A.; Hennek, Jonathan W.; Smith, Barbara; Kumar, Shailendra; Beattie, Patrick; Jain, Sidhartha; Rolland, Jason P.; Stossel, Thomas P.; Chunda-Liyoka, Catherine; Whitesides, George M.

In: Angewandte Chemie - International Edition, Vol. 54, No. 20, 11.05.2015, p. 5836-5853.

Research output: Contribution to journalArticle

Kumar, AA, Hennek, JW, Smith, B, Kumar, S, Beattie, P, Jain, S, Rolland, JP, Stossel, TP, Chunda-Liyoka, C & Whitesides, GM 2015, 'From the bench to the field in low-cost diagnostics: Two case studies', Angewandte Chemie - International Edition, vol. 54, no. 20, pp. 5836-5853. https://doi.org/10.1002/anie.201411741
Kumar, Ashok A. ; Hennek, Jonathan W. ; Smith, Barbara ; Kumar, Shailendra ; Beattie, Patrick ; Jain, Sidhartha ; Rolland, Jason P. ; Stossel, Thomas P. ; Chunda-Liyoka, Catherine ; Whitesides, George M. / From the bench to the field in low-cost diagnostics : Two case studies. In: Angewandte Chemie - International Edition. 2015 ; Vol. 54, No. 20. pp. 5836-5853.
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