Ferrite particles: A new magnetic resonance imaging contrast agent. Lack of acute or chronic hepatotoxicity after intravenous administration

Bruce R. Bacon, David D. Stark, Chanho H. Park, Sanjay Saini, Ernest V. Groman, Peter F. Hahn, Carolyn Compton, Joseph T. Ferrucci

Research output: Contribution to journalArticle

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Abstract

Intravenous administration of ferrite particles may be useful as contrast agents for magnetic resonance (MR) imaging of the liver. We studied several sensitive biochemical parameters of hepatocellular function and toxicity in rats after intravenous ferrite injections to determine whether there was any evidence of iron-induced hepatotoxicity. Light microscopy and iron determinations were performed on the liver, spleen, lung, and kidney. Forty-eight hours after a massive (250 mg iron per kilogram) ferrite injection, liver, spleen, and lung nonheme iron concentrations were markedly increased. Microscopy showed this iron to be entirely in reticuloendothellal cells. Despite the large increase in hepatic iron concentration, we found no evidence of hepatic mitochondrial or microsomal lipid peroxidation or organelle dysfunction, sensitive biochemical indicators of iron-induced hepatocellular injury. At 10 to 11 weeks after administration of ferrite in smaller doses (30 mg iron per kilogram), results of all biochemical and morphologic studies were normal. Furthermore, quantitative iron determinations and microscopic studies suggest that ferrite particles may be partially degraded and that iron is cleared from the liver during a 3-month period. Because ferrite particles are taken up by reticuloendothellal cells, hepatocellular function is not impaired and iron-induced hepatocellular injury does not occur.

Original languageEnglish (US)
Pages (from-to)164-171
Number of pages8
JournalThe Journal of Laboratory and Clinical Medicine
Volume110
Issue number2
StatePublished - 1987
Externally publishedYes

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Magnetic resonance
Intravenous Administration
Contrast Media
Ferrite
Iron
Magnetic Resonance Imaging
Imaging techniques
Liver
Microscopy
ferrite
Spleen
Lung
Wounds and Injuries
Intravenous Injections
Organelles
Lipid Peroxidation
Optical microscopy
Toxicity
Rats
Microscopic examination

ASJC Scopus subject areas

  • Medicine(all)
  • Pathology and Forensic Medicine

Cite this

Bacon, B. R., Stark, D. D., Park, C. H., Saini, S., Groman, E. V., Hahn, P. F., ... Ferrucci, J. T. (1987). Ferrite particles: A new magnetic resonance imaging contrast agent. Lack of acute or chronic hepatotoxicity after intravenous administration. The Journal of Laboratory and Clinical Medicine, 110(2), 164-171.

Ferrite particles : A new magnetic resonance imaging contrast agent. Lack of acute or chronic hepatotoxicity after intravenous administration. / Bacon, Bruce R.; Stark, David D.; Park, Chanho H.; Saini, Sanjay; Groman, Ernest V.; Hahn, Peter F.; Compton, Carolyn; Ferrucci, Joseph T.

In: The Journal of Laboratory and Clinical Medicine, Vol. 110, No. 2, 1987, p. 164-171.

Research output: Contribution to journalArticle

Bacon, Bruce R. ; Stark, David D. ; Park, Chanho H. ; Saini, Sanjay ; Groman, Ernest V. ; Hahn, Peter F. ; Compton, Carolyn ; Ferrucci, Joseph T. / Ferrite particles : A new magnetic resonance imaging contrast agent. Lack of acute or chronic hepatotoxicity after intravenous administration. In: The Journal of Laboratory and Clinical Medicine. 1987 ; Vol. 110, No. 2. pp. 164-171.
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