Exercise improves immune function, antidepressive response, and sleep quality in patients with chronic primary insomnia

Giselle Soares Passos, Dalva Poyares, Marcos Gonçalves Santana, Alexandre Abílio De Souza Teixeira, Fábio Santos Lira, Shawn Youngstedt, Ronaldo Vagner Thomatieli Dos Santos, Sergio Tufik, Marco Túlio De Mello

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The aim of this study was to evaluate the effects of moderate aerobic exercise training on sleep, depression, cortisol, and markers of immune function in patients with chronic primary insomnia. Twenty-one sedentary participants (16 women aged 44.7 ± 9 years) with chronic primary insomnia completed a 4-month intervention of moderate aerobic exercise. Compared with baseline, polysomnographic data showed improvements following exercise training. Also observed were reductions in depression symptoms and plasma cortisol. Immunologic assays revealed a significant increase in plasma apolipoprotein A (140.9 ± 22 to 151.2 ± 22 mg/dL) and decreases in CD4 (915.6 ± 361 to 789.6 ± 310 mm3) and CD8 (532.4 ± 259 to 435.7 ± 204 mm3). Decreases in cortisol were significantly correlated with increases in total sleep time (r=-0.51) and REM sleep (r=-0.52). In summary, long-term moderate aerobic exercise training improved sleep, reduced depression and cortisol, and promoted significant changes in immunologic variables.

Original languageEnglish (US)
Article number498961
JournalBioMed Research International
Volume2014
DOIs
StatePublished - 2014

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Sleep Initiation and Maintenance Disorders
Hydrocortisone
Sleep
Exercise
Depression
Apolipoproteins A
Plasmas
Assays
REM Sleep
Biomarkers

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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Exercise improves immune function, antidepressive response, and sleep quality in patients with chronic primary insomnia. / Passos, Giselle Soares; Poyares, Dalva; Santana, Marcos Gonçalves; Teixeira, Alexandre Abílio De Souza; Lira, Fábio Santos; Youngstedt, Shawn; Santos, Ronaldo Vagner Thomatieli Dos; Tufik, Sergio; De Mello, Marco Túlio.

In: BioMed Research International, Vol. 2014, 498961, 2014.

Research output: Contribution to journalArticle

Passos, GS, Poyares, D, Santana, MG, Teixeira, AADS, Lira, FS, Youngstedt, S, Santos, RVTD, Tufik, S & De Mello, MT 2014, 'Exercise improves immune function, antidepressive response, and sleep quality in patients with chronic primary insomnia', BioMed Research International, vol. 2014, 498961. https://doi.org/10.1155/2014/498961
Passos, Giselle Soares ; Poyares, Dalva ; Santana, Marcos Gonçalves ; Teixeira, Alexandre Abílio De Souza ; Lira, Fábio Santos ; Youngstedt, Shawn ; Santos, Ronaldo Vagner Thomatieli Dos ; Tufik, Sergio ; De Mello, Marco Túlio. / Exercise improves immune function, antidepressive response, and sleep quality in patients with chronic primary insomnia. In: BioMed Research International. 2014 ; Vol. 2014.
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AU - Lira, Fábio Santos

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