Entropy is a Simple Measure of the Antibody Profile and is an Indicator of Health Status: A Proof of Concept

Lu Wang, K. Whittemore, Stephen Johnston, Phillip Stafford

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We have previously shown that the diversity of antibodies in an individual can be displayed on chips on which 130,000 peptides chosen from random sequence space have been synthesized. This immunosignature technology is unbiased in displaying antibody diversity relative to natural sequence space, and has been shown to have diagnostic and prognostic potential for a wide variety of diseases and vaccines. Here we show that a global measure such as Shannon's entropy can be calculated for each immunosignature. The immune entropy was measured across a diverse set of 800 people and in 5 individuals over 3 months. The immune entropy is affected by some population characteristics and varies widely across individuals. We find that people with infections or breast cancer, generally have higher entropy values than non-diseased individuals. We propose that the immune entropy as measured from immunosignatures may be a simple method to monitor health in individuals and populations.

Original languageEnglish (US)
Article number18060
JournalScientific Reports
Volume7
Issue number1
DOIs
StatePublished - Dec 1 2017

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Health Status Indicators
Entropy
Antibody Diversity
Antibodies
Population Characteristics
Vaccines
Breast Neoplasms
Technology
Peptides
Health
Infection
Population

ASJC Scopus subject areas

  • General

Cite this

Entropy is a Simple Measure of the Antibody Profile and is an Indicator of Health Status : A Proof of Concept. / Wang, Lu; Whittemore, K.; Johnston, Stephen; Stafford, Phillip.

In: Scientific Reports, Vol. 7, No. 1, 18060, 01.12.2017.

Research output: Contribution to journalArticle

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