Endurance capacity, not body size, determines physical activity levels

Role of skeletal muscle PEPCK

Colleen M. Novak, Carlos Escande, Susan M. Gerber, Eduardo N. Chini, Minzhi Zhang, Steven L. Britton, Lauren G. Koch, James A. Levine

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Some people remain lean despite pressure to gain weight. Lean people tend to have high daily activity levels, but the source of this increased activity is unknown. We found that leanness cannot be accounted for by increased weight-corrected food intake in two different types of lean rats. As previously reported in lean people, we found that lean rats had higher daily activity levels; lean rats also expended more energy. These lean rats were developed through artificial selection for high aerobic endurance capacity. To test whether our findings extended to a human population, we measured endurance capacity using a VO2max treadmill test and daily activity in a group of non-exercising individuals. Similar to lean rats selectively bred for endurance capacity, our study revealed that people with higher VO2max also spent more time active throughout the day. Hence, endurance capacity may be the trait that underlies both physical activity levels and leanness. We identified one potential mechanism for the lean, active phenotype in rats, namely high levels of skeletal muscle PEPCK. Therefore, the lean phenotype is characterized by high endurance capacity and high activity and may stem from altered skeletal muscle energetics.

Original languageEnglish (US)
Article numbere5869
JournalPLoS One
Volume4
Issue number6
DOIs
StatePublished - Jun 12 2009
Externally publishedYes

Fingerprint

Body Size
physical activity
Muscle
skeletal muscle
Rats
Skeletal Muscle
Durability
body size
rats
Thinness
Phenotype
phenotype
Exercise equipment
exercise test
artificial selection
Exercise Test
human population
Weight Gain
food intake
Eating

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Novak, C. M., Escande, C., Gerber, S. M., Chini, E. N., Zhang, M., Britton, S. L., ... Levine, J. A. (2009). Endurance capacity, not body size, determines physical activity levels: Role of skeletal muscle PEPCK. PLoS One, 4(6), [e5869]. https://doi.org/10.1371/journal.pone.0005869

Endurance capacity, not body size, determines physical activity levels : Role of skeletal muscle PEPCK. / Novak, Colleen M.; Escande, Carlos; Gerber, Susan M.; Chini, Eduardo N.; Zhang, Minzhi; Britton, Steven L.; Koch, Lauren G.; Levine, James A.

In: PLoS One, Vol. 4, No. 6, e5869, 12.06.2009.

Research output: Contribution to journalArticle

Novak, CM, Escande, C, Gerber, SM, Chini, EN, Zhang, M, Britton, SL, Koch, LG & Levine, JA 2009, 'Endurance capacity, not body size, determines physical activity levels: Role of skeletal muscle PEPCK', PLoS One, vol. 4, no. 6, e5869. https://doi.org/10.1371/journal.pone.0005869
Novak, Colleen M. ; Escande, Carlos ; Gerber, Susan M. ; Chini, Eduardo N. ; Zhang, Minzhi ; Britton, Steven L. ; Koch, Lauren G. ; Levine, James A. / Endurance capacity, not body size, determines physical activity levels : Role of skeletal muscle PEPCK. In: PLoS One. 2009 ; Vol. 4, No. 6.
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