Efficient separation of dolaproine stereoisomers by optimization of a three component chromatographic solvent system

D. Kantoci, George Pettit, T. R. Wardlaw

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

A solvent system composed of n-hexane-chloroform-acetone was selected (by TLC) for resolving a difficult to separate mixture of protected dolaproine stereoisomers. A set of points representing solvent ratios was generated by an application of statistical methods. From thin layer chromatography data semifinal solvent ratios were selected. By applying simplex optimization, the solvent ratio was found to be 32.3 : 53.4 : 14.3 respectively for the preceding solvent system.

Original languageEnglish (US)
Pages (from-to)3915-3923
Number of pages9
JournalJournal of Liquid Chromatography
Volume13
Issue number20
DOIs
StatePublished - Jan 1 1990

ASJC Scopus subject areas

  • Molecular Medicine

Fingerprint Dive into the research topics of 'Efficient separation of dolaproine stereoisomers by optimization of a three component chromatographic solvent system'. Together they form a unique fingerprint.

Cite this