Efficient separation of dolaproine stereoisomers by optimization of a three component chromatographic solvent system

D. Kantoci; George Pettit; T. R. Wardlaw

doi:10.1080/01483919008049578

Efficient separation of dolaproine stereoisomers by optimization of a three component chromatographic solvent system

D. Kantoci, George Pettit, T. R. Wardlaw

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

A solvent system composed of n-hexane-chloroform-acetone was selected (by TLC) for resolving a difficult to separate mixture of protected dolaproine stereoisomers. A set of points representing solvent ratios was generated by an application of statistical methods. From thin layer chromatography data semifinal solvent ratios were selected. By applying simplex optimization, the solvent ratio was found to be 32.3 : 53.4 : 14.3 respectively for the preceding solvent system.

Original language	English (US)
Pages (from-to)	3915-3923
Number of pages	9
Journal	Journal of Liquid Chromatography
Volume	13
Issue number	20
DOIs	https://doi.org/10.1080/01483919008049578
State	Published - Jan 1 1990

ASJC Scopus subject areas

Molecular Medicine

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10.1080/01483919008049578

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abstract = "A solvent system composed of n-hexane-chloroform-acetone was selected (by TLC) for resolving a difficult to separate mixture of protected dolaproine stereoisomers. A set of points representing solvent ratios was generated by an application of statistical methods. From thin layer chromatography data semifinal solvent ratios were selected. By applying simplex optimization, the solvent ratio was found to be 32.3 : 53.4 : 14.3 respectively for the preceding solvent system.",

author = "D. Kantoci and George Pettit and Wardlaw, {T. R.}",

note = "Funding Information: Appreciation and thanks are extended for financial support provided by the National Cancer Institute Outstanding Investigator Grant CA44344-01A1, DHHS, the Fannie E. Rippel Foundation, the Robert B. Dalton Endowment Fund, Eleanor W. Libby, the Donald Ware Waddell Foundation, the Arizona Disease Control Research Commission, and the Eagles Art Ehrman Cancer Fund.",

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AU - Pettit, George

AU - Wardlaw, T. R.

N1 - Funding Information: Appreciation and thanks are extended for financial support provided by the National Cancer Institute Outstanding Investigator Grant CA44344-01A1, DHHS, the Fannie E. Rippel Foundation, the Robert B. Dalton Endowment Fund, Eleanor W. Libby, the Donald Ware Waddell Foundation, the Arizona Disease Control Research Commission, and the Eagles Art Ehrman Cancer Fund.

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AB - A solvent system composed of n-hexane-chloroform-acetone was selected (by TLC) for resolving a difficult to separate mixture of protected dolaproine stereoisomers. A set of points representing solvent ratios was generated by an application of statistical methods. From thin layer chromatography data semifinal solvent ratios were selected. By applying simplex optimization, the solvent ratio was found to be 32.3 : 53.4 : 14.3 respectively for the preceding solvent system.

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Efficient separation of dolaproine stereoisomers by optimization of a three component chromatographic solvent system

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