15 Citations (Scopus)

Abstract

Purpose This study aimed to compare 24-h and postprandial glucose responses to incremental intervals of standing (STAND), walking (WALK), and cycling (CYCLE) to a sit-only (SIT) condition. Methods Nine overweight/obese (body mass index = 29 ± 3 kg·m-2) adults (30 ± 15 yr) participated in this randomized crossover full-factorial study, with each condition performed 1 wk apart. STAND, CYCLE, and WALK intervals increased from 10 to 30 min·h-1 (2.5 h total) during an 8-h workday. WALK (1.0 mph) and STAND were matched for upright time, and WALK and CYCLE were matched for energy expenditure (2 METs). Continuous interstitial glucose monitoring was performed for 24 h to include the 8-h workday (LAB), after-work evening hours (EVE), and sleep (SLEEP). Three 2-h postprandial periods were also analyzed. Linear mixed models were used to test for condition differences. Results Compared with SIT (5.7 ± 1.0 mmol·L-1), mean 24-h glucose during STAND (5.4 ± 0.9 mmol·L-1) and WALK (5.3 ± 0.9 mmol·L-1) were lower, and CYCLE (5.1 ± 1.0 mmol·L-1) was lower than all other conditions (all P < 0.001). During LAB and EVE, mean glucose was lower for STAND, WALK, and CYCLE compared with SIT (P < 0.001). During SLEEP, the mean glucose for CYCLE was lower than all other conditions (P < 0.001). Compared with SIT, cumulative 6-h postprandial mean glucose was 5%-12% lower (P < 0.001) during STAND, WALK, and CYCLE, and 6-h postprandial glucose integrated area under the curve was 24% lower during WALK (P < 0.05) and 44% lower during CYCLE (P < 0.001). Conclusions Replacing sitting with regular intervals of standing or light-intensity activity during an 8-h workday reduces 24-h and postprandial glucose. These effects persist during evening hours, with CYCLE having the largest and most sustained effect.

Original languageEnglish (US)
Pages (from-to)2503-2511
Number of pages9
JournalMedicine and Science in Sports and Exercise
Volume48
Issue number12
DOIs
StatePublished - Dec 1 2016

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Walking
Light
Glucose
Postprandial Period
Energy Metabolism
Area Under Curve
Linear Models
Sleep
Body Mass Index

Keywords

  • DIABETES
  • GLYCEMIA
  • PHYSICAL INACTIVITY
  • POSTPRANDIAL
  • PROLONGED SITTING

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Effects of Standing and Light-Intensity Walking and Cycling on 24-h Glucose. / Crespo, Noe C.; Mullane, Sarah L.; Zeigler, Zachary S.; Buman, Matthew; Gaesser, Glenn.

In: Medicine and Science in Sports and Exercise, Vol. 48, No. 12, 01.12.2016, p. 2503-2511.

Research output: Contribution to journalArticle

Crespo, Noe C. ; Mullane, Sarah L. ; Zeigler, Zachary S. ; Buman, Matthew ; Gaesser, Glenn. / Effects of Standing and Light-Intensity Walking and Cycling on 24-h Glucose. In: Medicine and Science in Sports and Exercise. 2016 ; Vol. 48, No. 12. pp. 2503-2511.
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abstract = "Purpose This study aimed to compare 24-h and postprandial glucose responses to incremental intervals of standing (STAND), walking (WALK), and cycling (CYCLE) to a sit-only (SIT) condition. Methods Nine overweight/obese (body mass index = 29 ± 3 kg·m-2) adults (30 ± 15 yr) participated in this randomized crossover full-factorial study, with each condition performed 1 wk apart. STAND, CYCLE, and WALK intervals increased from 10 to 30 min·h-1 (2.5 h total) during an 8-h workday. WALK (1.0 mph) and STAND were matched for upright time, and WALK and CYCLE were matched for energy expenditure (2 METs). Continuous interstitial glucose monitoring was performed for 24 h to include the 8-h workday (LAB), after-work evening hours (EVE), and sleep (SLEEP). Three 2-h postprandial periods were also analyzed. Linear mixed models were used to test for condition differences. Results Compared with SIT (5.7 ± 1.0 mmol·L-1), mean 24-h glucose during STAND (5.4 ± 0.9 mmol·L-1) and WALK (5.3 ± 0.9 mmol·L-1) were lower, and CYCLE (5.1 ± 1.0 mmol·L-1) was lower than all other conditions (all P < 0.001). During LAB and EVE, mean glucose was lower for STAND, WALK, and CYCLE compared with SIT (P < 0.001). During SLEEP, the mean glucose for CYCLE was lower than all other conditions (P < 0.001). Compared with SIT, cumulative 6-h postprandial mean glucose was 5{\%}-12{\%} lower (P < 0.001) during STAND, WALK, and CYCLE, and 6-h postprandial glucose integrated area under the curve was 24{\%} lower during WALK (P < 0.05) and 44{\%} lower during CYCLE (P < 0.001). Conclusions Replacing sitting with regular intervals of standing or light-intensity activity during an 8-h workday reduces 24-h and postprandial glucose. These effects persist during evening hours, with CYCLE having the largest and most sustained effect.",
keywords = "DIABETES, GLYCEMIA, PHYSICAL INACTIVITY, POSTPRANDIAL, PROLONGED SITTING",
author = "Crespo, {Noe C.} and Mullane, {Sarah L.} and Zeigler, {Zachary S.} and Matthew Buman and Glenn Gaesser",
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T1 - Effects of Standing and Light-Intensity Walking and Cycling on 24-h Glucose

AU - Crespo, Noe C.

AU - Mullane, Sarah L.

AU - Zeigler, Zachary S.

AU - Buman, Matthew

AU - Gaesser, Glenn

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Purpose This study aimed to compare 24-h and postprandial glucose responses to incremental intervals of standing (STAND), walking (WALK), and cycling (CYCLE) to a sit-only (SIT) condition. Methods Nine overweight/obese (body mass index = 29 ± 3 kg·m-2) adults (30 ± 15 yr) participated in this randomized crossover full-factorial study, with each condition performed 1 wk apart. STAND, CYCLE, and WALK intervals increased from 10 to 30 min·h-1 (2.5 h total) during an 8-h workday. WALK (1.0 mph) and STAND were matched for upright time, and WALK and CYCLE were matched for energy expenditure (2 METs). Continuous interstitial glucose monitoring was performed for 24 h to include the 8-h workday (LAB), after-work evening hours (EVE), and sleep (SLEEP). Three 2-h postprandial periods were also analyzed. Linear mixed models were used to test for condition differences. Results Compared with SIT (5.7 ± 1.0 mmol·L-1), mean 24-h glucose during STAND (5.4 ± 0.9 mmol·L-1) and WALK (5.3 ± 0.9 mmol·L-1) were lower, and CYCLE (5.1 ± 1.0 mmol·L-1) was lower than all other conditions (all P < 0.001). During LAB and EVE, mean glucose was lower for STAND, WALK, and CYCLE compared with SIT (P < 0.001). During SLEEP, the mean glucose for CYCLE was lower than all other conditions (P < 0.001). Compared with SIT, cumulative 6-h postprandial mean glucose was 5%-12% lower (P < 0.001) during STAND, WALK, and CYCLE, and 6-h postprandial glucose integrated area under the curve was 24% lower during WALK (P < 0.05) and 44% lower during CYCLE (P < 0.001). Conclusions Replacing sitting with regular intervals of standing or light-intensity activity during an 8-h workday reduces 24-h and postprandial glucose. These effects persist during evening hours, with CYCLE having the largest and most sustained effect.

AB - Purpose This study aimed to compare 24-h and postprandial glucose responses to incremental intervals of standing (STAND), walking (WALK), and cycling (CYCLE) to a sit-only (SIT) condition. Methods Nine overweight/obese (body mass index = 29 ± 3 kg·m-2) adults (30 ± 15 yr) participated in this randomized crossover full-factorial study, with each condition performed 1 wk apart. STAND, CYCLE, and WALK intervals increased from 10 to 30 min·h-1 (2.5 h total) during an 8-h workday. WALK (1.0 mph) and STAND were matched for upright time, and WALK and CYCLE were matched for energy expenditure (2 METs). Continuous interstitial glucose monitoring was performed for 24 h to include the 8-h workday (LAB), after-work evening hours (EVE), and sleep (SLEEP). Three 2-h postprandial periods were also analyzed. Linear mixed models were used to test for condition differences. Results Compared with SIT (5.7 ± 1.0 mmol·L-1), mean 24-h glucose during STAND (5.4 ± 0.9 mmol·L-1) and WALK (5.3 ± 0.9 mmol·L-1) were lower, and CYCLE (5.1 ± 1.0 mmol·L-1) was lower than all other conditions (all P < 0.001). During LAB and EVE, mean glucose was lower for STAND, WALK, and CYCLE compared with SIT (P < 0.001). During SLEEP, the mean glucose for CYCLE was lower than all other conditions (P < 0.001). Compared with SIT, cumulative 6-h postprandial mean glucose was 5%-12% lower (P < 0.001) during STAND, WALK, and CYCLE, and 6-h postprandial glucose integrated area under the curve was 24% lower during WALK (P < 0.05) and 44% lower during CYCLE (P < 0.001). Conclusions Replacing sitting with regular intervals of standing or light-intensity activity during an 8-h workday reduces 24-h and postprandial glucose. These effects persist during evening hours, with CYCLE having the largest and most sustained effect.

KW - DIABETES

KW - GLYCEMIA

KW - PHYSICAL INACTIVITY

KW - POSTPRANDIAL

KW - PROLONGED SITTING

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DO - 10.1249/MSS.0000000000001062

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JO - Medicine and Science in Sports and Exercise

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