Effects of exercise training intensity on nocturnal growth hormone secretion in obese adults with the metabolic syndrome

Brian A. Irving, J. Y. Weltman, James T. Patrie, Christopher K. Davis, David W. Brock, Damon Swift, Eugene J. Barrett, Glenn Gaesser, Arthur Weltman

    Research output: Contribution to journalArticle

    22 Citations (Scopus)

    Abstract

    Context: Abdominal adiposity is associated with reduced spontaneous GH secretion, and an increased incidence of the metabolic syndrome, type 2 diabetes, and cardiovascular disease. Exercise training increases GH secretion, induces abdominal visceral fat loss, and has been shown to improve the cardiometabolic risk factor profile. However, little is known about the effects of endurance training intensity on spontaneous GH release in obese individuals. Objective: Our objective was to examine the effects of 16 wk endurance training on spontaneous 12-h overnight GH secretion in adults with the metabolic syndrome. Design and Setting: This randomized, controlled exercise intervention was conducted at the University of Virginia. Participants: A total of 34 adults with the metabolic syndrome (mean ± SEM: age: 49.1 ± 1.8 yr) participated. Intervention: Participants were randomized to one of three groups for 16 wk: no exercise training (control), low-intensity exercise training, or high-intensity training. Main Outcome Measure: Change in nocturnal integrated GH area under the curve (AUC) was calculated. Results: Both exercise training conditions augmented within-group nocturnal GH AUC pretrain to post-training (low-intensity exercise training approximately ↑ 49%, P < 0.05; and high-intensity training approximately ↑ 65%, P < 0.01), and these changes were also greater than the changes in the control group (P < 0.01). The change in nocturnal GH AUC was inversely associated with the change in fat mass across the entire sample (r = -0.34; P = 0.051; n = 34) but was not significantly associated with the change in abdominal visceral fat (r = 0.02; P = 0.920; n = 34). Conclusions: Sixteen wk of supervised exercise training in adults with the metabolic syndrome increases spontaneous nocturnal GH secretion independent of exercise training intensity.

    Original languageEnglish (US)
    Pages (from-to)1979-1986
    Number of pages8
    JournalJournal of Clinical Endocrinology and Metabolism
    Volume94
    Issue number6
    DOIs
    StatePublished - Jun 2009

    Fingerprint

    Growth Hormone
    Exercise
    Area Under Curve
    Intra-Abdominal Fat
    Fats
    Durability
    Adiposity
    Medical problems
    Type 2 Diabetes Mellitus
    Cardiovascular Diseases
    Outcome Assessment (Health Care)
    Control Groups
    Scanning electron microscopy
    Incidence

    ASJC Scopus subject areas

    • Biochemistry
    • Clinical Biochemistry
    • Endocrinology
    • Biochemistry, medical
    • Endocrinology, Diabetes and Metabolism

    Cite this

    Effects of exercise training intensity on nocturnal growth hormone secretion in obese adults with the metabolic syndrome. / Irving, Brian A.; Weltman, J. Y.; Patrie, James T.; Davis, Christopher K.; Brock, David W.; Swift, Damon; Barrett, Eugene J.; Gaesser, Glenn; Weltman, Arthur.

    In: Journal of Clinical Endocrinology and Metabolism, Vol. 94, No. 6, 06.2009, p. 1979-1986.

    Research output: Contribution to journalArticle

    Irving, Brian A. ; Weltman, J. Y. ; Patrie, James T. ; Davis, Christopher K. ; Brock, David W. ; Swift, Damon ; Barrett, Eugene J. ; Gaesser, Glenn ; Weltman, Arthur. / Effects of exercise training intensity on nocturnal growth hormone secretion in obese adults with the metabolic syndrome. In: Journal of Clinical Endocrinology and Metabolism. 2009 ; Vol. 94, No. 6. pp. 1979-1986.
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    abstract = "Context: Abdominal adiposity is associated with reduced spontaneous GH secretion, and an increased incidence of the metabolic syndrome, type 2 diabetes, and cardiovascular disease. Exercise training increases GH secretion, induces abdominal visceral fat loss, and has been shown to improve the cardiometabolic risk factor profile. However, little is known about the effects of endurance training intensity on spontaneous GH release in obese individuals. Objective: Our objective was to examine the effects of 16 wk endurance training on spontaneous 12-h overnight GH secretion in adults with the metabolic syndrome. Design and Setting: This randomized, controlled exercise intervention was conducted at the University of Virginia. Participants: A total of 34 adults with the metabolic syndrome (mean ± SEM: age: 49.1 ± 1.8 yr) participated. Intervention: Participants were randomized to one of three groups for 16 wk: no exercise training (control), low-intensity exercise training, or high-intensity training. Main Outcome Measure: Change in nocturnal integrated GH area under the curve (AUC) was calculated. Results: Both exercise training conditions augmented within-group nocturnal GH AUC pretrain to post-training (low-intensity exercise training approximately ↑ 49{\%}, P < 0.05; and high-intensity training approximately ↑ 65{\%}, P < 0.01), and these changes were also greater than the changes in the control group (P < 0.01). The change in nocturnal GH AUC was inversely associated with the change in fat mass across the entire sample (r = -0.34; P = 0.051; n = 34) but was not significantly associated with the change in abdominal visceral fat (r = 0.02; P = 0.920; n = 34). Conclusions: Sixteen wk of supervised exercise training in adults with the metabolic syndrome increases spontaneous nocturnal GH secretion independent of exercise training intensity.",
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    T1 - Effects of exercise training intensity on nocturnal growth hormone secretion in obese adults with the metabolic syndrome

    AU - Irving, Brian A.

    AU - Weltman, J. Y.

    AU - Patrie, James T.

    AU - Davis, Christopher K.

    AU - Brock, David W.

    AU - Swift, Damon

    AU - Barrett, Eugene J.

    AU - Gaesser, Glenn

    AU - Weltman, Arthur

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    N2 - Context: Abdominal adiposity is associated with reduced spontaneous GH secretion, and an increased incidence of the metabolic syndrome, type 2 diabetes, and cardiovascular disease. Exercise training increases GH secretion, induces abdominal visceral fat loss, and has been shown to improve the cardiometabolic risk factor profile. However, little is known about the effects of endurance training intensity on spontaneous GH release in obese individuals. Objective: Our objective was to examine the effects of 16 wk endurance training on spontaneous 12-h overnight GH secretion in adults with the metabolic syndrome. Design and Setting: This randomized, controlled exercise intervention was conducted at the University of Virginia. Participants: A total of 34 adults with the metabolic syndrome (mean ± SEM: age: 49.1 ± 1.8 yr) participated. Intervention: Participants were randomized to one of three groups for 16 wk: no exercise training (control), low-intensity exercise training, or high-intensity training. Main Outcome Measure: Change in nocturnal integrated GH area under the curve (AUC) was calculated. Results: Both exercise training conditions augmented within-group nocturnal GH AUC pretrain to post-training (low-intensity exercise training approximately ↑ 49%, P < 0.05; and high-intensity training approximately ↑ 65%, P < 0.01), and these changes were also greater than the changes in the control group (P < 0.01). The change in nocturnal GH AUC was inversely associated with the change in fat mass across the entire sample (r = -0.34; P = 0.051; n = 34) but was not significantly associated with the change in abdominal visceral fat (r = 0.02; P = 0.920; n = 34). Conclusions: Sixteen wk of supervised exercise training in adults with the metabolic syndrome increases spontaneous nocturnal GH secretion independent of exercise training intensity.

    AB - Context: Abdominal adiposity is associated with reduced spontaneous GH secretion, and an increased incidence of the metabolic syndrome, type 2 diabetes, and cardiovascular disease. Exercise training increases GH secretion, induces abdominal visceral fat loss, and has been shown to improve the cardiometabolic risk factor profile. However, little is known about the effects of endurance training intensity on spontaneous GH release in obese individuals. Objective: Our objective was to examine the effects of 16 wk endurance training on spontaneous 12-h overnight GH secretion in adults with the metabolic syndrome. Design and Setting: This randomized, controlled exercise intervention was conducted at the University of Virginia. Participants: A total of 34 adults with the metabolic syndrome (mean ± SEM: age: 49.1 ± 1.8 yr) participated. Intervention: Participants were randomized to one of three groups for 16 wk: no exercise training (control), low-intensity exercise training, or high-intensity training. Main Outcome Measure: Change in nocturnal integrated GH area under the curve (AUC) was calculated. Results: Both exercise training conditions augmented within-group nocturnal GH AUC pretrain to post-training (low-intensity exercise training approximately ↑ 49%, P < 0.05; and high-intensity training approximately ↑ 65%, P < 0.01), and these changes were also greater than the changes in the control group (P < 0.01). The change in nocturnal GH AUC was inversely associated with the change in fat mass across the entire sample (r = -0.34; P = 0.051; n = 34) but was not significantly associated with the change in abdominal visceral fat (r = 0.02; P = 0.920; n = 34). Conclusions: Sixteen wk of supervised exercise training in adults with the metabolic syndrome increases spontaneous nocturnal GH secretion independent of exercise training intensity.

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