Effect of age on glucose oxidation by isolated rat islets

G. M. Reaven, P. D. Reaven

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Islets were isolated from pancreases of 2-month and 12-month-old rats, and the oxidation of14C-glucose to14CO2 determined at various medium D-glucose concentration. Islets from 12-month-old rats oxidized significantly less glucose than those from 2-month-old rats at glucose concentrations of 150, 300, and 450 mg/dl, and this was true when islets were selected by hand or by Ficoll density gradient separation. The effect of age on glucose oxidation was seen when islets were incubated with [U-14C], [1-14C], or [6-14C] glucose. The results raise the possibility that previously reported age-related defects in glucose-stimulated insulin secretion may be secondary to the effect of age on islet glucose catabolism.

Original languageEnglish (US)
Pages (from-to)69-71
Number of pages3
JournalDiabetologia
Volume18
Issue number1
DOIs
StatePublished - Jan 1 1980
Externally publishedYes

Keywords

  • Age
  • glucose
  • glucose oxidation
  • insulin
  • insulin secretion
  • islet glucose metabolism
  • isolated islets

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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