Early onset of electrical activity in developing neurons cultured on carbon nanotube immobilized microelectrodes

Massoud Louis Khraiche, Nathan Jackson, Jitendran Muthuswamy

Research output: Chapter in Book/Report/Conference proceedingConference contribution

12 Scopus citations

Abstract

In this study, we test the hypothesis that increased surface roughness due to carbon nanotubes (CNTs) enhances neuronal adhesion and consequently electrical excitability of single neurons. Neurons are grown on CNT modified microelectrode arrays (MEAs). Multi-unit activity was seen as early as 4 days after seeding compared to 7 days in control cultures on microelectrodes without CNTs. The results overall, show earlier onset and higher level of electrical activity in neurons seeded on CNT modified MEAs compared to non-modified control MEAs. We conclude that CNTs on microelectrodes enhance electrical excitability of single neurons in culture.

Original languageEnglish (US)
Title of host publicationProceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
Pages777-780
Number of pages4
DOIs
Publication statusPublished - 2009
Event31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 - Minneapolis, MN, United States
Duration: Sep 2 2009Sep 6 2009

Other

Other31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
CountryUnited States
CityMinneapolis, MN
Period9/2/099/6/09

    Fingerprint

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology
  • Biomedical Engineering
  • Medicine(all)

Cite this

Khraiche, M. L., Jackson, N., & Muthuswamy, J. (2009). Early onset of electrical activity in developing neurons cultured on carbon nanotube immobilized microelectrodes. In Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 (pp. 777-780). [5333590] https://doi.org/10.1109/IEMBS.2009.5333590