TY - GEN
T1 - Early onset of electrical activity in developing neurons cultured on carbon nanotube immobilized microelectrodes
AU - Khraiche, Massoud Louis
AU - Jackson, Nathan
AU - Muthuswamy, Jitendran
PY - 2009
Y1 - 2009
N2 - In this study, we test the hypothesis that increased surface roughness due to carbon nanotubes (CNTs) enhances neuronal adhesion and consequently electrical excitability of single neurons. Neurons are grown on CNT modified microelectrode arrays (MEAs). Multi-unit activity was seen as early as 4 days after seeding compared to 7 days in control cultures on microelectrodes without CNTs. The results overall, show earlier onset and higher level of electrical activity in neurons seeded on CNT modified MEAs compared to non-modified control MEAs. We conclude that CNTs on microelectrodes enhance electrical excitability of single neurons in culture.
AB - In this study, we test the hypothesis that increased surface roughness due to carbon nanotubes (CNTs) enhances neuronal adhesion and consequently electrical excitability of single neurons. Neurons are grown on CNT modified microelectrode arrays (MEAs). Multi-unit activity was seen as early as 4 days after seeding compared to 7 days in control cultures on microelectrodes without CNTs. The results overall, show earlier onset and higher level of electrical activity in neurons seeded on CNT modified MEAs compared to non-modified control MEAs. We conclude that CNTs on microelectrodes enhance electrical excitability of single neurons in culture.
UR - http://www.scopus.com/inward/record.url?scp=77951004276&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77951004276&partnerID=8YFLogxK
U2 - 10.1109/IEMBS.2009.5333590
DO - 10.1109/IEMBS.2009.5333590
M3 - Conference contribution
C2 - 19964241
AN - SCOPUS:77951004276
SN - 9781424432967
T3 - Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
SP - 777
EP - 780
BT - Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society
PB - IEEE Computer Society
T2 - 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
Y2 - 2 September 2009 through 6 September 2009
ER -