Dorsal hippocampus inhibition disrupts acquisition and expression, but not consolidation, of cocaine conditioned place preference

Ryan A. Meyers, Arturo R. Zavala, Colenso M. Speer, Janet Neisewander

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Cocaine abusers may experience drug craving upon exposure to environmental contexts where cocaine was experienced. The dorsal hippocampus (DHC) is important for contextual conditioning, therefore the authors examined the specific role of the DHC in cocaine conditioned place preference (CPP). Muscimol was used to temporarily inhibit the DHC and was infused before conditioning sessions or tests for CPP to investigate acquisition and expression of cocaine CPP, respectively. To investigate consolidation, rats received intra-DHC muscimol either immediately or 6 hr after conditioning sessions. Inhibition of DHC, but not the overlying cortex, disrupted acquisition and expression of cocaine CPP. It is interesting to note that there was no effect of postconditioning DHC inhibition. The findings suggest that the DHC is important for both acquisition and recall, but not consolidation, of context-cocaine associations.

Original languageEnglish (US)
Pages (from-to)401-412
Number of pages12
JournalBehavioral Neuroscience
Volume120
Issue number2
DOIs
StatePublished - Apr 2006

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Cocaine
Hippocampus
Muscimol
Environmental Exposure
Inhibition (Psychology)
Pharmaceutical Preparations
Conditioning (Psychology)

Keywords

  • Cocaine-seeking behavior
  • Drug abuse
  • Hippocampus
  • Incentive motivation
  • Memory

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Clinical Psychology

Cite this

Dorsal hippocampus inhibition disrupts acquisition and expression, but not consolidation, of cocaine conditioned place preference. / Meyers, Ryan A.; Zavala, Arturo R.; Speer, Colenso M.; Neisewander, Janet.

In: Behavioral Neuroscience, Vol. 120, No. 2, 04.2006, p. 401-412.

Research output: Contribution to journalArticle

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