DNA methylation in social insects: How epigenetics can control behavior and longevity

Hua Yan, Roberto Bonasio, Daniel F. Simola, Juergen Liebig, Shelley L. Berger, Danny Reinberg

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

In eusocial insects, genetically identical individuals can exhibit striking differences in behavior and longevity. The molecular basis of such phenotypic plasticity is of great interest to the scientific community. DNA methylation, as well as other epigenetic signals, plays an important role in modulating gene expression and can therefore establish, sustain, and alter organism-level phenotypes, including behavior and life span. Unlike DNA methylation in mammals, DNA methylation in insects, including eusocial insects, is enriched in gene bodies of actively expressed genes. Recent investigations have revealed the important role of gene body methylation in regulating gene expression in response to intrinsic and environmental factors. In this review, we summarize recent advances in DNA methylation research and discuss its significance in our understanding of the epigenetic underpinnings of behavior and longevity.

Original languageEnglish (US)
Pages (from-to)435-452
Number of pages18
JournalAnnual Review of Entomology
Volume60
DOIs
StatePublished - Jan 7 2015

Fingerprint

social insect
social insects
methylation
DNA methylation
epigenetics
DNA
insects
insect
gene expression
gene
genes
phenotypic plasticity
mammals
phenotype
environmental factor
mammal
environmental factors
organisms

Keywords

  • Alternative splicing
  • Environment
  • Gene body methylation
  • Plasticity
  • Transcription

ASJC Scopus subject areas

  • Insect Science
  • Ecology, Evolution, Behavior and Systematics

Cite this

DNA methylation in social insects : How epigenetics can control behavior and longevity. / Yan, Hua; Bonasio, Roberto; Simola, Daniel F.; Liebig, Juergen; Berger, Shelley L.; Reinberg, Danny.

In: Annual Review of Entomology, Vol. 60, 07.01.2015, p. 435-452.

Research output: Contribution to journalArticle

Yan, Hua ; Bonasio, Roberto ; Simola, Daniel F. ; Liebig, Juergen ; Berger, Shelley L. ; Reinberg, Danny. / DNA methylation in social insects : How epigenetics can control behavior and longevity. In: Annual Review of Entomology. 2015 ; Vol. 60. pp. 435-452.
@article{6488d284628e4c348a7a37c89e76b460,
title = "DNA methylation in social insects: How epigenetics can control behavior and longevity",
abstract = "In eusocial insects, genetically identical individuals can exhibit striking differences in behavior and longevity. The molecular basis of such phenotypic plasticity is of great interest to the scientific community. DNA methylation, as well as other epigenetic signals, plays an important role in modulating gene expression and can therefore establish, sustain, and alter organism-level phenotypes, including behavior and life span. Unlike DNA methylation in mammals, DNA methylation in insects, including eusocial insects, is enriched in gene bodies of actively expressed genes. Recent investigations have revealed the important role of gene body methylation in regulating gene expression in response to intrinsic and environmental factors. In this review, we summarize recent advances in DNA methylation research and discuss its significance in our understanding of the epigenetic underpinnings of behavior and longevity.",
keywords = "Alternative splicing, Environment, Gene body methylation, Plasticity, Transcription",
author = "Hua Yan and Roberto Bonasio and Simola, {Daniel F.} and Juergen Liebig and Berger, {Shelley L.} and Danny Reinberg",
year = "2015",
month = "1",
day = "7",
doi = "10.1146/annurev-ento-010814-020803",
language = "English (US)",
volume = "60",
pages = "435--452",
journal = "Annual Review of Entomology",
issn = "0066-4170",
publisher = "Annual Reviews Inc.",

}

TY - JOUR

T1 - DNA methylation in social insects

T2 - How epigenetics can control behavior and longevity

AU - Yan, Hua

AU - Bonasio, Roberto

AU - Simola, Daniel F.

AU - Liebig, Juergen

AU - Berger, Shelley L.

AU - Reinberg, Danny

PY - 2015/1/7

Y1 - 2015/1/7

N2 - In eusocial insects, genetically identical individuals can exhibit striking differences in behavior and longevity. The molecular basis of such phenotypic plasticity is of great interest to the scientific community. DNA methylation, as well as other epigenetic signals, plays an important role in modulating gene expression and can therefore establish, sustain, and alter organism-level phenotypes, including behavior and life span. Unlike DNA methylation in mammals, DNA methylation in insects, including eusocial insects, is enriched in gene bodies of actively expressed genes. Recent investigations have revealed the important role of gene body methylation in regulating gene expression in response to intrinsic and environmental factors. In this review, we summarize recent advances in DNA methylation research and discuss its significance in our understanding of the epigenetic underpinnings of behavior and longevity.

AB - In eusocial insects, genetically identical individuals can exhibit striking differences in behavior and longevity. The molecular basis of such phenotypic plasticity is of great interest to the scientific community. DNA methylation, as well as other epigenetic signals, plays an important role in modulating gene expression and can therefore establish, sustain, and alter organism-level phenotypes, including behavior and life span. Unlike DNA methylation in mammals, DNA methylation in insects, including eusocial insects, is enriched in gene bodies of actively expressed genes. Recent investigations have revealed the important role of gene body methylation in regulating gene expression in response to intrinsic and environmental factors. In this review, we summarize recent advances in DNA methylation research and discuss its significance in our understanding of the epigenetic underpinnings of behavior and longevity.

KW - Alternative splicing

KW - Environment

KW - Gene body methylation

KW - Plasticity

KW - Transcription

UR - http://www.scopus.com/inward/record.url?scp=84920862329&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84920862329&partnerID=8YFLogxK

U2 - 10.1146/annurev-ento-010814-020803

DO - 10.1146/annurev-ento-010814-020803

M3 - Article

C2 - 25341091

AN - SCOPUS:84920862329

VL - 60

SP - 435

EP - 452

JO - Annual Review of Entomology

JF - Annual Review of Entomology

SN - 0066-4170

ER -