Distribution patterns of variability for 18 immune system genes in Amerindians - relationship with history and epidemiology

J. D. Lindenau, F. M. Salzano, L. S P Guimarães, S. M. Callegari-Jacques, Ana Hurtado, Kim Hill, M. L. Petzl-Erler, L. T. Tsuneto, M. H. Hutz

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Native American populations generally have a higher prevalence of infectious diseases than non-Native populations and this fact can induce different pressures in their immune system. We investigated the patterns of population differentiation (FST) of 32 polymorphisms related to adaptive immune response in four Native American populations (Aché, Guarani-Kaiowá, Guarani-Ñandeva and Kaingang), and the results were compared with the three major world population data [Yoruba of Ibadan, Nigeria (YRI), Utah residents with northern and Western Europe ancestry (CEU) and Han Chinese of Beijing, China (CHB)] available in the HapMap database. The Aché clearly differentiated from the other Amerindians, but when all Native Americans were compared with the samples of other ethnic groups the lowest difference (0.08) was found with CHB (Asians), the second lowest (0.15) with YRI (Africans) and the most marked with CEU (European-derived). The considerable intra and interethnic differences found can be explained both in terms of diverse evolutionary distances and more recent environmental pathogen exposures; and they should be appropriately considered prior to any specific public health action.

Original languageEnglish (US)
Pages (from-to)177-185
Number of pages9
JournalTissue Antigens
Volume82
Issue number3
DOIs
StatePublished - Sep 2013

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Immune System
Epidemiology
History
North American Indians
Population
Genes
Nigeria
China
HapMap Project
Environmental Exposure
Adaptive Immunity
Ethnic Groups
Communicable Diseases
Public Health
Databases
Pressure
Beijing

Keywords

  • Aché
  • Amerindians
  • Guarani
  • Immune response genes
  • Interleukins
  • Kaingang

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Genetics

Cite this

Distribution patterns of variability for 18 immune system genes in Amerindians - relationship with history and epidemiology. / Lindenau, J. D.; Salzano, F. M.; Guimarães, L. S P; Callegari-Jacques, S. M.; Hurtado, Ana; Hill, Kim; Petzl-Erler, M. L.; Tsuneto, L. T.; Hutz, M. H.

In: Tissue Antigens, Vol. 82, No. 3, 09.2013, p. 177-185.

Research output: Contribution to journalArticle

Lindenau, JD, Salzano, FM, Guimarães, LSP, Callegari-Jacques, SM, Hurtado, A, Hill, K, Petzl-Erler, ML, Tsuneto, LT & Hutz, MH 2013, 'Distribution patterns of variability for 18 immune system genes in Amerindians - relationship with history and epidemiology', Tissue Antigens, vol. 82, no. 3, pp. 177-185. https://doi.org/10.1111/tan.12183
Lindenau, J. D. ; Salzano, F. M. ; Guimarães, L. S P ; Callegari-Jacques, S. M. ; Hurtado, Ana ; Hill, Kim ; Petzl-Erler, M. L. ; Tsuneto, L. T. ; Hutz, M. H. / Distribution patterns of variability for 18 immune system genes in Amerindians - relationship with history and epidemiology. In: Tissue Antigens. 2013 ; Vol. 82, No. 3. pp. 177-185.
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