Discovery of STL polyomavirus, a polyomavirus of ancestral recombinant origin that encodes a unique T antigen by alternative splicing

Efrem Lim, Alejandro Reyes, Martin Antonio, Debasish Saha, Usman N. Ikumapayi, Mitchell Adeyemi, O. Colin Stine, Rebecca Skelton, Daniel C. Brennan, Rajhab S. Mkakosya, Mark J. Manary, Jeffrey I. Gordon, David Wang

Research output: Contribution to journalArticle

109 Citations (Scopus)

Abstract

The family Polyomaviridae is comprised of circular double-stranded DNA viruses, several of which are associated with diseases, including cancer, in immunocompromised patients. Here we describe a novel polyomavirus recovered from the fecal microbiota of a child in Malawi, provisionally named STL polyomavirus (STLPyV). We detected STLPyV in clinical stool specimens from USA and The Gambia at up to 1% frequency. Complete genome comparisons of two STLPyV strains demonstrated 5.2% nucleotide divergence. Alternative splicing of the STLPyV early region yielded a unique form of T antigen, which we named 229T, in addition to the expected large and small T antigens. STLPyV has a mosaic genome and shares an ancestral recombinant origin with MWPyV. The discovery of STLPyV highlights a novel alternative splicing strategy and advances our understanding of the complex evolutionary history of polyomaviruses.

Original languageEnglish (US)
Pages (from-to)295-303
Number of pages9
JournalVirology
Volume436
Issue number2
DOIs
StatePublished - Feb 20 2013
Externally publishedYes

Fingerprint

Polyomavirus
Viral Tumor Antigens
Alternative Splicing
Polyomaviridae
Genome
Gambia
Malawi
DNA Viruses
Microbiota
Immunocompromised Host
Nucleotides
History
DNA

Keywords

  • Alternative splicing
  • Polyomavirus
  • Recombination
  • Tumor antigen
  • Virus discovery

ASJC Scopus subject areas

  • Virology

Cite this

Discovery of STL polyomavirus, a polyomavirus of ancestral recombinant origin that encodes a unique T antigen by alternative splicing. / Lim, Efrem; Reyes, Alejandro; Antonio, Martin; Saha, Debasish; Ikumapayi, Usman N.; Adeyemi, Mitchell; Stine, O. Colin; Skelton, Rebecca; Brennan, Daniel C.; Mkakosya, Rajhab S.; Manary, Mark J.; Gordon, Jeffrey I.; Wang, David.

In: Virology, Vol. 436, No. 2, 20.02.2013, p. 295-303.

Research output: Contribution to journalArticle

Lim, E, Reyes, A, Antonio, M, Saha, D, Ikumapayi, UN, Adeyemi, M, Stine, OC, Skelton, R, Brennan, DC, Mkakosya, RS, Manary, MJ, Gordon, JI & Wang, D 2013, 'Discovery of STL polyomavirus, a polyomavirus of ancestral recombinant origin that encodes a unique T antigen by alternative splicing', Virology, vol. 436, no. 2, pp. 295-303. https://doi.org/10.1016/j.virol.2012.12.005
Lim, Efrem ; Reyes, Alejandro ; Antonio, Martin ; Saha, Debasish ; Ikumapayi, Usman N. ; Adeyemi, Mitchell ; Stine, O. Colin ; Skelton, Rebecca ; Brennan, Daniel C. ; Mkakosya, Rajhab S. ; Manary, Mark J. ; Gordon, Jeffrey I. ; Wang, David. / Discovery of STL polyomavirus, a polyomavirus of ancestral recombinant origin that encodes a unique T antigen by alternative splicing. In: Virology. 2013 ; Vol. 436, No. 2. pp. 295-303.
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