Glycans are ubiquitous biomolecules that are usually conjugated to proteins and lipids (Glycoconjugates), which circulate within the body and decorate the surface of all cells. Because of their structural diversity and plasticity, sugars display a complex profile (GlycoSignature) on glycoconjugates and hence the cell surface. GlycoSignatures are specific for organisms, species, and tissue/cell types and also reflect physiological states such as diseases and other forms of stresses. GlycoSignatures are therefore excellent indicators of altered physiological states that can be measured on cell surface and in body fluids, e.g., serum, urine, saliva and corneal fluid. Most existing biological sensors used in the field of glycobiology are time consuming; require multiple chemical reactions and/or large instruments for detection of UV, visible or IR signals. A label-free (potentially dry) biosensor for biomolecular recognition events involving electrical measurements, described in this invention, does not involve chemical modifications but has the advantage of rapid (real-time) and label-free detection.
|Original language||English (US)|
|State||Published - Dec 20 2005|