Differential Impedance Spectroscopy Based Label-Free GlycoSensor - "A Sweet Sensor"

Terry Alford (Inventor), Jeffrey LaBelle (Inventor), Peiming Zhang (Inventor)

Research output: Patent

Abstract

Glycans are ubiquitous biomolecules that are usually conjugated to proteins and lipids (Glycoconjugates), which circulate within the body and decorate the surface of all cells. Because of their structural diversity and plasticity, sugars display a complex profile (GlycoSignature) on glycoconjugates and hence the cell surface. GlycoSignatures are specific for organisms, species, and tissue/cell types and also reflect physiological states such as diseases and other forms of stresses. GlycoSignatures are therefore excellent indicators of altered physiological states that can be measured on cell surface and in body fluids, e.g., serum, urine, saliva and corneal fluid. Most existing biological sensors used in the field of glycobiology are time consuming; require multiple chemical reactions and/or large instruments for detection of UV, visible or IR signals. A label-free (potentially dry) biosensor for biomolecular recognition events involving electrical measurements, described in this invention, does not involve chemical modifications but has the advantage of rapid (real-time) and label-free detection.
Original languageEnglish (US)
StatePublished - Dec 20 2005

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Labels
Glycoconjugates
Spectroscopy
Sensors
Body fluids
Chemical modification
Patents and inventions
Biomolecules
Biosensors
Sugars
Polysaccharides
Plasticity
Chemical reactions
Tissue
Lipids
Fluids
Proteins
Glycomics

Cite this

Differential Impedance Spectroscopy Based Label-Free GlycoSensor - "A Sweet Sensor". / Alford, Terry (Inventor); LaBelle, Jeffrey (Inventor); Zhang, Peiming (Inventor).

Research output: Patent

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abstract = "Glycans are ubiquitous biomolecules that are usually conjugated to proteins and lipids (Glycoconjugates), which circulate within the body and decorate the surface of all cells. Because of their structural diversity and plasticity, sugars display a complex profile (GlycoSignature) on glycoconjugates and hence the cell surface. GlycoSignatures are specific for organisms, species, and tissue/cell types and also reflect physiological states such as diseases and other forms of stresses. GlycoSignatures are therefore excellent indicators of altered physiological states that can be measured on cell surface and in body fluids, e.g., serum, urine, saliva and corneal fluid. Most existing biological sensors used in the field of glycobiology are time consuming; require multiple chemical reactions and/or large instruments for detection of UV, visible or IR signals. A label-free (potentially dry) biosensor for biomolecular recognition events involving electrical measurements, described in this invention, does not involve chemical modifications but has the advantage of rapid (real-time) and label-free detection.",
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T1 - Differential Impedance Spectroscopy Based Label-Free GlycoSensor - "A Sweet Sensor"

AU - Alford, Terry

AU - LaBelle, Jeffrey

AU - Zhang, Peiming

PY - 2005/12/20

Y1 - 2005/12/20

N2 - Glycans are ubiquitous biomolecules that are usually conjugated to proteins and lipids (Glycoconjugates), which circulate within the body and decorate the surface of all cells. Because of their structural diversity and plasticity, sugars display a complex profile (GlycoSignature) on glycoconjugates and hence the cell surface. GlycoSignatures are specific for organisms, species, and tissue/cell types and also reflect physiological states such as diseases and other forms of stresses. GlycoSignatures are therefore excellent indicators of altered physiological states that can be measured on cell surface and in body fluids, e.g., serum, urine, saliva and corneal fluid. Most existing biological sensors used in the field of glycobiology are time consuming; require multiple chemical reactions and/or large instruments for detection of UV, visible or IR signals. A label-free (potentially dry) biosensor for biomolecular recognition events involving electrical measurements, described in this invention, does not involve chemical modifications but has the advantage of rapid (real-time) and label-free detection.

AB - Glycans are ubiquitous biomolecules that are usually conjugated to proteins and lipids (Glycoconjugates), which circulate within the body and decorate the surface of all cells. Because of their structural diversity and plasticity, sugars display a complex profile (GlycoSignature) on glycoconjugates and hence the cell surface. GlycoSignatures are specific for organisms, species, and tissue/cell types and also reflect physiological states such as diseases and other forms of stresses. GlycoSignatures are therefore excellent indicators of altered physiological states that can be measured on cell surface and in body fluids, e.g., serum, urine, saliva and corneal fluid. Most existing biological sensors used in the field of glycobiology are time consuming; require multiple chemical reactions and/or large instruments for detection of UV, visible or IR signals. A label-free (potentially dry) biosensor for biomolecular recognition events involving electrical measurements, described in this invention, does not involve chemical modifications but has the advantage of rapid (real-time) and label-free detection.

M3 - Patent

ER -