@article{61bc9a59c0e34e739888966d2e81dc5b,
title = "Designer DNA nanostructures for therapeutics",
abstract = "The field of structural DNA nanotechnology applies the programmability of Watson-Crick base pairing to the construction of custom nanostructures that are prescribed by the sequence information encoded in DNA molecules. Precisely defined geometries, highly programmable molecular interactions, and outstanding biocompatibility make DNA nanostructures a new category of nanocarriers for drug delivery. Over the past decade, the potential of using DNA nanocarrier-based formulation for cancer therapy has been extensively explored with the successful implementation of various therapeutic strategies, both in vitro and in vivo. Moreover, DNA nanocarriers can be encoded with complex instructions via sequence design, enabling therapeutic functions to be executed in a programmed, automatic manner. In this review, we summarize recent advances and discuss the challenges and opportunities in designer DNA nanostructure-enabled therapeutics.",
keywords = "SDG3: Good health and well-being, acute kidney injury, cancer therapeutics, drug delivery, nanocarrier, structural DNA nanotechnology, therapeutic DNA nanorobot",
author = "Shuoxing Jiang and Zhilei Ge and Shan Mou and Hao Yan and Chunhai Fan",
note = "Funding Information: This work was financially supported by the National Key R&D Program of China ( 2016YFA0400900 and 2016YFA0902600 ), the National Natural Science Foundation of China ( 21991134 , 21834007 , 21675167 , 31571014 , 11575278 , and 21505148 ), the National Science Foundation ( 1607832 ), Shanghai Municipal Science and Technology Commission ( 19JC1410302 ), the Open Large Infrastructure Research of Chinese Academy of Sciences , and the LU JIAXI International team program . C.F. acknowledges the K.C. Wong Education Foundation (SJTU). H.Y. acknowledges the Presidential Strategic Initiative Fund from Arizona State University. Funding Information: This work was financially supported by the National Key R&D Program of China (2016YFA0400900 and 2016YFA0902600), the National Natural Science Foundation of China (21991134, 21834007, 21675167, 31571014, 11575278, and 21505148), the National Science Foundation (1607832), Shanghai Municipal Science and Technology Commission (19JC1410302), the Open Large Infrastructure Research of Chinese Academy of Sciences, and the LU JIAXI International team program. C.F. acknowledges the K.C. Wong Education Foundation (SJTU). H.Y. acknowledges the Presidential Strategic Initiative Fund from Arizona State University. S.J. Z.G. and S.M. investigated the literature and wrote and revised the manuscript. C.F. and H.Y. supervised the writing of the manuscript and revised the manuscript. Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2021",
month = may,
day = "13",
doi = "10.1016/j.chempr.2020.10.025",
language = "English (US)",
volume = "7",
pages = "1156--1179",
journal = "Chem",
issn = "2451-9308",
publisher = "Elsevier Inc.",
number = "5",
}