Design and synthesis of heterocyclic carboxamides as natural nucleic acid base mimics

D. E. Bergtrom, P. Zhang, W. T. Johnson

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

A series of heterocyclic carboxamides have been designed as mimics for the natural nucleic acid bases. The nucleosides 1-(2'-deoxy-β-D-ribofuranosyl)imidazole-4-carboxamide (1), 1-(2'-deoxy-β-D-ribofuranosyl)pyrazole-3-carboxamide (2), and 1-(2'deoxy-β-D-ribofuranosyl)pyrrole-3-carboxamide (3) were synthesized and their structures confirmed by spectroscopic and analytical means.

Original languageEnglish (US)
Pages (from-to)59-68
Number of pages10
JournalNucleosides and Nucleotides
Volume15
Issue number1-3
DOIs
StatePublished - 1996

ASJC Scopus subject areas

  • Biochemistry
  • Genetics

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