Design and modeling of a peptide based nanotweezer

Gaurav Sharma; Kaushal Rege; Constantinos Mavroidis; Martin L. Yarmush

doi:10.1115/detc2006-99701

Design and modeling of a peptide based nanotweezer

Gaurav Sharma, Kaushal Rege, Constantinos Mavroidis, Martin L. Yarmush

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

5 Scopus citations

Abstract

The design hypothesis, architectures, and preliminary computational results of a peptide based nanoTweezer are presented in this paper. We engineered the α-helical coiled coil portion of the yeast transcriptional activator peptide called GCN4 to obtain an environmentally-responsive nanoTweezer. The dimeric coiled coil peptide consists of two identical ∼4.5 nm long and ∼3 nm wide polypeptide chains. The actuation mechanism depends on the modifying electrostatic charges along the peptide by varying the pH of the solution resulting in the reversible movement of helices and therefore, creating the motion of the tweezer. Preliminary molecular dynamics results indicated that pH changes led to a reversible deflection of 1-2 nm with the nanoTweezer. The force profile of the nanoTweezer motion and some potential applications are also discussed.

Original language	English (US)
Title of host publication	Proceedings of 2006 ASME International Design Engineering Technical Conferences and Computers and Information In Engineering Conference, DETC2006
Publisher	American Society of Mechanical Engineers
ISBN (Print)	079183784X, 9780791837849
DOIs	https://doi.org/10.1115/detc2006-99701
State	Published - 2006
Externally published	Yes
Event	2006 ASME International Design Engineering Technical Conferences and Computers and Information In Engineering Conference, DETC2006 - Philadelphia, PA, United States Duration: Sep 10 2006 → Sep 13 2006

Publication series

Name	Proceedings of the ASME Design Engineering Technical Conference
Volume	2006

Other

Other	2006 ASME International Design Engineering Technical Conferences and Computers and Information In Engineering Conference, DETC2006
Country/Territory	United States
City	Philadelphia, PA
Period	9/10/06 → 9/13/06

ASJC Scopus subject areas

Modeling and Simulation
Mechanical Engineering
Computer Science Applications
Computer Graphics and Computer-Aided Design

Access to Document

10.1115/detc2006-99701

Cite this

Sharma, G., Rege, K., Mavroidis, C., & Yarmush, M. L. (2006). Design and modeling of a peptide based nanotweezer. In Proceedings of 2006 ASME International Design Engineering Technical Conferences and Computers and Information In Engineering Conference, DETC2006 (Proceedings of the ASME Design Engineering Technical Conference; Vol. 2006). American Society of Mechanical Engineers. https://doi.org/10.1115/detc2006-99701

Design and modeling of a peptide based nanotweezer. / Sharma, Gaurav; Rege, Kaushal; Mavroidis, Constantinos et al.
Proceedings of 2006 ASME International Design Engineering Technical Conferences and Computers and Information In Engineering Conference, DETC2006. American Society of Mechanical Engineers, 2006. (Proceedings of the ASME Design Engineering Technical Conference; Vol. 2006).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Sharma, G, Rege, K, Mavroidis, C & Yarmush, ML 2006, Design and modeling of a peptide based nanotweezer. in Proceedings of 2006 ASME International Design Engineering Technical Conferences and Computers and Information In Engineering Conference, DETC2006. Proceedings of the ASME Design Engineering Technical Conference, vol. 2006, American Society of Mechanical Engineers, 2006 ASME International Design Engineering Technical Conferences and Computers and Information In Engineering Conference, DETC2006, Philadelphia, PA, United States, 9/10/06. https://doi.org/10.1115/detc2006-99701

Sharma G, Rege K, Mavroidis C, Yarmush ML. Design and modeling of a peptide based nanotweezer. In Proceedings of 2006 ASME International Design Engineering Technical Conferences and Computers and Information In Engineering Conference, DETC2006. American Society of Mechanical Engineers. 2006. (Proceedings of the ASME Design Engineering Technical Conference). doi: 10.1115/detc2006-99701

Sharma, Gaurav ; Rege, Kaushal ; Mavroidis, Constantinos et al. / Design and modeling of a peptide based nanotweezer. Proceedings of 2006 ASME International Design Engineering Technical Conferences and Computers and Information In Engineering Conference, DETC2006. American Society of Mechanical Engineers, 2006. (Proceedings of the ASME Design Engineering Technical Conference).

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AB - The design hypothesis, architectures, and preliminary computational results of a peptide based nanoTweezer are presented in this paper. We engineered the α-helical coiled coil portion of the yeast transcriptional activator peptide called GCN4 to obtain an environmentally-responsive nanoTweezer. The dimeric coiled coil peptide consists of two identical ∼4.5 nm long and ∼3 nm wide polypeptide chains. The actuation mechanism depends on the modifying electrostatic charges along the peptide by varying the pH of the solution resulting in the reversible movement of helices and therefore, creating the motion of the tweezer. Preliminary molecular dynamics results indicated that pH changes led to a reversible deflection of 1-2 nm with the nanoTweezer. The force profile of the nanoTweezer motion and some potential applications are also discussed.

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Design and modeling of a peptide based nanotweezer

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