Dendritic changes in Alzheimer's disease and factors that may underlie these changes

Brian H. Anderton; Linda Callahan; Paul Coleman; Peter Davies; Dorothy Flood; Gregory A. Jicha; Thomas Ohm; Charles Weaver

doi:10.1016/S0301-0082(98)00022-7

Dendritic changes in Alzheimer's disease and factors that may underlie these changes

Brian H. Anderton, Linda Callahan, Paul Coleman, Peter Davies, Dorothy Flood, Gregory A. Jicha, Thomas Ohm, Charles Weaver

Research output: Contribution to journal › Article › peer-review

90 Scopus citations

Abstract

It seems likely that the Alzheimer disease (AD)-related dendritic changes addressed in this article are induced by two principally different processes. One process is linked to the plastic response associated with deafferentation, that is, long-lasting transneuronally induced regressive changes in dendritic geometry and structure. The other process is associated with severe alterations of the dendritic- and perikaryal cytoskeleton as seen in neurons with the neurofibrillary pathology of AD, that is, the formation of paired helical filaments formed by hyperphosphorylated microtubule- associated protein tau. As the development of dendritic and cytoskeletal abnormalities are at least mediated by alterations in signal transduction, this article also reviews changes in signal pathways in AD. We also discuss transgenic approaches developed to model and understand cytoskeletal abnormalities.

Original language	English (US)
Pages (from-to)	595-609
Number of pages	15
Journal	Progress in Neurobiology
Volume	55
Issue number	6
DOIs	https://doi.org/10.1016/S0301-0082(98)00022-7
State	Published - Aug 1 1998
Externally published	Yes

ASJC Scopus subject areas

General Neuroscience

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10.1016/S0301-0082(98)00022-7

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title = "Dendritic changes in Alzheimer's disease and factors that may underlie these changes",

abstract = "It seems likely that the Alzheimer disease (AD)-related dendritic changes addressed in this article are induced by two principally different processes. One process is linked to the plastic response associated with deafferentation, that is, long-lasting transneuronally induced regressive changes in dendritic geometry and structure. The other process is associated with severe alterations of the dendritic- and perikaryal cytoskeleton as seen in neurons with the neurofibrillary pathology of AD, that is, the formation of paired helical filaments formed by hyperphosphorylated microtubule- associated protein tau. As the development of dendritic and cytoskeletal abnormalities are at least mediated by alterations in signal transduction, this article also reviews changes in signal pathways in AD. We also discuss transgenic approaches developed to model and understand cytoskeletal abnormalities.",

author = "Anderton, {Brian H.} and Linda Callahan and Paul Coleman and Peter Davies and Dorothy Flood and Jicha, {Gregory A.} and Thomas Ohm and Charles Weaver",

note = "Funding Information: The work of P.D., C.W. and G.A.J. is supported by NIMH Grant No. MH38623 and NIA Grant No. 06803. T.G.O. is supported by SFB 507-C2 and Hertie Stiftung Grant Nos OH 48/4-2, OH 48/1-3.",

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doi = "10.1016/S0301-0082(98)00022-7",

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T1 - Dendritic changes in Alzheimer's disease and factors that may underlie these changes

AU - Anderton, Brian H.

AU - Callahan, Linda

AU - Coleman, Paul

AU - Davies, Peter

AU - Flood, Dorothy

AU - Jicha, Gregory A.

AU - Ohm, Thomas

AU - Weaver, Charles

N1 - Funding Information: The work of P.D., C.W. and G.A.J. is supported by NIMH Grant No. MH38623 and NIA Grant No. 06803. T.G.O. is supported by SFB 507-C2 and Hertie Stiftung Grant Nos OH 48/4-2, OH 48/1-3.

PY - 1998/8/1

Y1 - 1998/8/1

N2 - It seems likely that the Alzheimer disease (AD)-related dendritic changes addressed in this article are induced by two principally different processes. One process is linked to the plastic response associated with deafferentation, that is, long-lasting transneuronally induced regressive changes in dendritic geometry and structure. The other process is associated with severe alterations of the dendritic- and perikaryal cytoskeleton as seen in neurons with the neurofibrillary pathology of AD, that is, the formation of paired helical filaments formed by hyperphosphorylated microtubule- associated protein tau. As the development of dendritic and cytoskeletal abnormalities are at least mediated by alterations in signal transduction, this article also reviews changes in signal pathways in AD. We also discuss transgenic approaches developed to model and understand cytoskeletal abnormalities.

AB - It seems likely that the Alzheimer disease (AD)-related dendritic changes addressed in this article are induced by two principally different processes. One process is linked to the plastic response associated with deafferentation, that is, long-lasting transneuronally induced regressive changes in dendritic geometry and structure. The other process is associated with severe alterations of the dendritic- and perikaryal cytoskeleton as seen in neurons with the neurofibrillary pathology of AD, that is, the formation of paired helical filaments formed by hyperphosphorylated microtubule- associated protein tau. As the development of dendritic and cytoskeletal abnormalities are at least mediated by alterations in signal transduction, this article also reviews changes in signal pathways in AD. We also discuss transgenic approaches developed to model and understand cytoskeletal abnormalities.

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JO - Progress in Neurobiology

JF - Progress in Neurobiology

IS - 6

ER -

Dendritic changes in Alzheimer's disease and factors that may underlie these changes

Abstract

ASJC Scopus subject areas

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