Decline in sulfadoxine-pyrimethamine-resistant alleles after change in drug policy in the Amazon region of Peru

Zhiyong Zhou, Sean M. Griffing, Alexandre Macedo De Oliveira, Andrea M. McCollum, Wilmer Marquino Quezada, Nancy Arrospide, Ananias A. Escalante, Venkatachalam Udhayakumar

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

The frequency of alleles with triple mutations conferring sulfadoxine-pyrimethamine (SP) resistance in the Peruvian Amazon Basin has declined (16.9% for dhfr and 0% for dhps compared to 47% for both alleles in 1997) 5 years after SP was replaced as the first-line treatment for Plasmodium falciparum malaria. Microsatellite analysis showed that the dhfr and dhps alleles are of common origin.

Original languageEnglish (US)
Pages (from-to)739-741
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume52
Issue number2
DOIs
StatePublished - Feb 1 2008

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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    Zhou, Z., Griffing, S. M., De Oliveira, A. M., McCollum, A. M., Quezada, W. M., Arrospide, N., Escalante, A. A., & Udhayakumar, V. (2008). Decline in sulfadoxine-pyrimethamine-resistant alleles after change in drug policy in the Amazon region of Peru. Antimicrobial Agents and Chemotherapy, 52(2), 739-741. https://doi.org/10.1128/AAC.00975-07