TY - JOUR
T1 - Decline in sulfadoxine-pyrimethamine-resistant alleles after change in drug policy in the Amazon region of Peru
AU - Zhou, Zhiyong
AU - Griffing, Sean M.
AU - De Oliveira, Alexandre Macedo
AU - McCollum, Andrea M.
AU - Quezada, Wilmer Marquino
AU - Arrospide, Nancy
AU - Escalante, Ananias A.
AU - Udhayakumar, Venkatachalam
PY - 2008/2
Y1 - 2008/2
N2 - The frequency of alleles with triple mutations conferring sulfadoxine-pyrimethamine (SP) resistance in the Peruvian Amazon Basin has declined (16.9% for dhfr and 0% for dhps compared to 47% for both alleles in 1997) 5 years after SP was replaced as the first-line treatment for Plasmodium falciparum malaria. Microsatellite analysis showed that the dhfr and dhps alleles are of common origin.
AB - The frequency of alleles with triple mutations conferring sulfadoxine-pyrimethamine (SP) resistance in the Peruvian Amazon Basin has declined (16.9% for dhfr and 0% for dhps compared to 47% for both alleles in 1997) 5 years after SP was replaced as the first-line treatment for Plasmodium falciparum malaria. Microsatellite analysis showed that the dhfr and dhps alleles are of common origin.
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U2 - 10.1128/AAC.00975-07
DO - 10.1128/AAC.00975-07
M3 - Article
C2 - 18025120
AN - SCOPUS:38649109842
SN - 0066-4804
VL - 52
SP - 739
EP - 741
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 2
ER -