Culturability and Secondary Metabolite Diversity of Extreme Microbes: Expanding Contribution of Deep Sea and Deep-Sea Vent Microbes to Natural Product Discovery

Robin Pettit

Research output: Contribution to journalReview articlepeer-review

77 Scopus citations

Abstract

Microbes from extreme environments do not necessarily require extreme culture conditions. Perhaps the most extreme environments known, deep-sea hydrothermal vent sites, support an incredible array of archaea, bacteria, and fungi, many of which have now been cultured. Microbes cultured from extreme environments have not disappointed in the natural products arena; diverse bioactive secondary metabolites have been isolated from cultured extreme-tolerant microbes, extremophiles, and deep-sea microbes. The contribution of vent microbes to our arsenal of natural products will likely grow, given the culturability of vent microbes; their metabolic, physiologic, and phylogenetic diversity; numerous reports of bioactive natural products from microbes inhabiting high acid, high temperature, or high pressure environments; and the recent isolation of new chroman derivatives and siderophores from deep-sea hydrothermal vent bacteria.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalMarine Biotechnology
Volume13
Issue number1
DOIs
StatePublished - Feb 2011

Keywords

  • Deep-sea hydrothermal vent
  • Extremophile
  • Natural product
  • Secondary metabolite

ASJC Scopus subject areas

  • Biotechnology
  • Aquatic Science

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