Secretion of digestive enzymes by the exocrine pancreas is thought to be initiated by a rise in cytosol Ca2+ activity. It is not yet clear whether influx of extracellular calcium or release of calcium from an intracellular site is responsible for this event. Review of the literature provides evidence that both extracellular and intracellular calcium regulate secretion and that under different circumstances each may be an important source of 'messenger' calcium.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Pharmacology, Toxicology and Pharmaceutics(all)