Control of pancreatic enzyme secretion: A critique on the role of calcium

Douglas E. Chandler

Research output: Contribution to journalShort survey

16 Scopus citations


Secretion of digestive enzymes by the exocrine pancreas is thought to be initiated by a rise in cytosol Ca2+ activity. It is not yet clear whether influx of extracellular calcium or release of calcium from an intracellular site is responsible for this event. Review of the literature provides evidence that both extracellular and intracellular calcium regulate secretion and that under different circumstances each may be an important source of 'messenger' calcium.

Original languageEnglish (US)
Pages (from-to)323-333
Number of pages11
JournalLife Sciences
Issue number4
StatePublished - Jul 24 1978


ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this