Control of pancreatic enzyme secretion: A critique on the role of calcium

Douglas E. Chandler

doi:10.1016/0024-3205(78)90016-4

Control of pancreatic enzyme secretion: A critique on the role of calcium

Douglas E. Chandler

Arizona State University

Research output: Contribution to journal › Short survey › peer-review

Abstract

Secretion of digestive enzymes by the exocrine pancreas is thought to be initiated by a rise in cytosol Ca²⁺ activity. It is not yet clear whether influx of extracellular calcium or release of calcium from an intracellular site is responsible for this event. Review of the literature provides evidence that both extracellular and intracellular calcium regulate secretion and that under different circumstances each may be an important source of 'messenger' calcium.

Original language	English (US)
Pages (from-to)	323-333
Number of pages	11
Journal	Life Sciences
Volume	23
Issue number	4
DOIs	https://doi.org/10.1016/0024-3205(78)90016-4
State	Published - Jul 24 1978

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/0024-3205(78)90016-4

Cite this

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title = "Control of pancreatic enzyme secretion: A critique on the role of calcium",

abstract = "Secretion of digestive enzymes by the exocrine pancreas is thought to be initiated by a rise in cytosol Ca2+ activity. It is not yet clear whether influx of extracellular calcium or release of calcium from an intracellular site is responsible for this event. Review of the literature provides evidence that both extracellular and intracellular calcium regulate secretion and that under different circumstances each may be an important source of 'messenger' calcium.",

author = "Chandler, {Douglas E.}",

note = "Funding Information: I thank Dr . John A . Williams for critical comments on this manuscript and for our many fruitful discussions during its preparation . This article was written during tenure of a USPHS fellowship (GM 00927) . Some of the studies described were supported by grants from the National Cystic Fibrosis Research Foundation and the USPHS (GM 19998) to Dr . Williams .",

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N1 - Funding Information: I thank Dr . John A . Williams for critical comments on this manuscript and for our many fruitful discussions during its preparation . This article was written during tenure of a USPHS fellowship (GM 00927) . Some of the studies described were supported by grants from the National Cystic Fibrosis Research Foundation and the USPHS (GM 19998) to Dr . Williams .

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N2 - Secretion of digestive enzymes by the exocrine pancreas is thought to be initiated by a rise in cytosol Ca2+ activity. It is not yet clear whether influx of extracellular calcium or release of calcium from an intracellular site is responsible for this event. Review of the literature provides evidence that both extracellular and intracellular calcium regulate secretion and that under different circumstances each may be an important source of 'messenger' calcium.

AB - Secretion of digestive enzymes by the exocrine pancreas is thought to be initiated by a rise in cytosol Ca2+ activity. It is not yet clear whether influx of extracellular calcium or release of calcium from an intracellular site is responsible for this event. Review of the literature provides evidence that both extracellular and intracellular calcium regulate secretion and that under different circumstances each may be an important source of 'messenger' calcium.

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JO - Life Sciences

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IS - 4

ER -

Control of pancreatic enzyme secretion: A critique on the role of calcium

Abstract

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