Conformation sequence recovery of a nonperiodic object from a diffraction-beforedestruction experiment

Chun Hong Yoon; Miriam Barthelmess; Richard J. Bean; Flavio Capotondi; Richard A. Kirian; Maya Kiskinova; Emanuele Pedersoli; Lorenzo Raimondi; Francesco Stellato; Fenglin Wang; Henry N. Chapman

doi:10.1364/OE.22.008085

Conformation sequence recovery of a nonperiodic object from a diffraction-beforedestruction experiment

Chun Hong Yoon, Miriam Barthelmess, Richard J. Bean, Flavio Capotondi, Richard A. Kirian, Maya Kiskinova, Emanuele Pedersoli, Lorenzo Raimondi, Francesco Stellato, Fenglin Wang, Henry N. Chapman

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Knowledge of the sequence of different conformational states of a protein molecule is key to better understanding its biological function. A diffraction pattern from a single conformational state can be captured with an ultrafast X-ray Free-Electron Laser (XFEL) before the target is completely annihilated by the radiation. In this paper, we report the first experimental demonstration of conformation sequence recovery using diffraction patterns from randomly ordered conformations of a non-periodic object using the dimensional reduction technique Isomap and coherent diffraction imaging.

Original language	English (US)
Pages (from-to)	8085-8093
Number of pages	9
Journal	Optics Express
Volume	22
Issue number	7
DOIs	https://doi.org/10.1364/OE.22.008085
State	Published - 2014
Externally published	Yes

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics

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title = "Conformation sequence recovery of a nonperiodic object from a diffraction-beforedestruction experiment",

abstract = "Knowledge of the sequence of different conformational states of a protein molecule is key to better understanding its biological function. A diffraction pattern from a single conformational state can be captured with an ultrafast X-ray Free-Electron Laser (XFEL) before the target is completely annihilated by the radiation. In this paper, we report the first experimental demonstration of conformation sequence recovery using diffraction patterns from randomly ordered conformations of a non-periodic object using the dimensional reduction technique Isomap and coherent diffraction imaging.",

author = "Yoon, {Chun Hong} and Miriam Barthelmess and Bean, {Richard J.} and Flavio Capotondi and Kirian, {Richard A.} and Maya Kiskinova and Emanuele Pedersoli and Lorenzo Raimondi and Francesco Stellato and Fenglin Wang and Chapman, {Henry N.}",

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doi = "10.1364/OE.22.008085",

language = "English (US)",

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T1 - Conformation sequence recovery of a nonperiodic object from a diffraction-beforedestruction experiment

AU - Yoon, Chun Hong

AU - Barthelmess, Miriam

AU - Bean, Richard J.

AU - Capotondi, Flavio

AU - Kirian, Richard A.

AU - Kiskinova, Maya

AU - Pedersoli, Emanuele

AU - Raimondi, Lorenzo

AU - Stellato, Francesco

AU - Wang, Fenglin

AU - Chapman, Henry N.

PY - 2014

Y1 - 2014

N2 - Knowledge of the sequence of different conformational states of a protein molecule is key to better understanding its biological function. A diffraction pattern from a single conformational state can be captured with an ultrafast X-ray Free-Electron Laser (XFEL) before the target is completely annihilated by the radiation. In this paper, we report the first experimental demonstration of conformation sequence recovery using diffraction patterns from randomly ordered conformations of a non-periodic object using the dimensional reduction technique Isomap and coherent diffraction imaging.

AB - Knowledge of the sequence of different conformational states of a protein molecule is key to better understanding its biological function. A diffraction pattern from a single conformational state can be captured with an ultrafast X-ray Free-Electron Laser (XFEL) before the target is completely annihilated by the radiation. In this paper, we report the first experimental demonstration of conformation sequence recovery using diffraction patterns from randomly ordered conformations of a non-periodic object using the dimensional reduction technique Isomap and coherent diffraction imaging.

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EP - 8093

JO - Optics Express

JF - Optics Express

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ER -

Conformation sequence recovery of a nonperiodic object from a diffraction-beforedestruction experiment

Abstract

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