Conformation sequence recovery of a nonperiodic object from a diffraction-beforedestruction experiment

Chun Hong Yoon, Miriam Barthelmess, Richard J. Bean, Flavio Capotondi, Richard A. Kirian, Maya Kiskinova, Emanuele Pedersoli, Lorenzo Raimondi, Francesco Stellato, Fenglin Wang, Henry N. Chapman

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Knowledge of the sequence of different conformational states of a protein molecule is key to better understanding its biological function. A diffraction pattern from a single conformational state can be captured with an ultrafast X-ray Free-Electron Laser (XFEL) before the target is completely annihilated by the radiation. In this paper, we report the first experimental demonstration of conformation sequence recovery using diffraction patterns from randomly ordered conformations of a non-periodic object using the dimensional reduction technique Isomap and coherent diffraction imaging.

Original languageEnglish (US)
Pages (from-to)8085-8093
Number of pages9
JournalOptics Express
Volume22
Issue number7
DOIs
StatePublished - Jan 1 2014

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

Fingerprint Dive into the research topics of 'Conformation sequence recovery of a nonperiodic object from a diffraction-beforedestruction experiment'. Together they form a unique fingerprint.

  • Cite this

    Yoon, C. H., Barthelmess, M., Bean, R. J., Capotondi, F., Kirian, R. A., Kiskinova, M., Pedersoli, E., Raimondi, L., Stellato, F., Wang, F., & Chapman, H. N. (2014). Conformation sequence recovery of a nonperiodic object from a diffraction-beforedestruction experiment. Optics Express, 22(7), 8085-8093. https://doi.org/10.1364/OE.22.008085